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【结 构 式】 
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【药物名称】Compound 73/602, CDRI-73/602 【化学名称】7-Methoxy-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-one 【CA登记号】60811-32-7 【 分 子 式 】C12H12N2O2 【 分 子 量 】216.24164 |
【开发单位】Central Drug Research Institute (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS |
合成路线1
A new method for the synthesis of compound 73/602 has been reported: By cyclocondensantion of 5-methoxyanthranilic acid (I) with 2-pyrrolidinone (II) in the presence of POCl3 or SOCl2.
| 【1】 Karimov, A.; Yunusov, S.; Telezhenetskaya, M.V.; Synthetic analogs of Peganum alkaloids. 1. Synthesis of methoxy- and hydroxysubstituted desoxyvasicinones and desocypeganines. Khim Prir Soedin 1982, 4, 498-504. |
合成路线2
The compound 73/602 is synthesized by refluxing 5-methoxyanthranilic acid (I) with O-ethyl butyrolactim (II) in dry benzene for 5 hours.
| 【1】 Arya, V.P.; Compound 73/602. Drugs Fut 1982, 7, 8, 549. |
| 【2】 Kapil, R.S.; Devi, G.; Popli, S.P.; Potential CNS and CVS agents: Synthesis based on vasicinone. Indian J Chem 1976, 14B, 354-356. |
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