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【结 构 式】 
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【药物名称】Saussureamine A 【化学名称】(+)-1-[(3R,3aS,6E,10E,11aS)-6,10-Dimethyl-2-oxo-2,3,3a,4,5,8,9,11a-octahydrocyclodeca[b]furan-3-ylmethyl]pyrrolidine-2(S)-carboxylic acid 【CA登记号】148245-82-3 【 分 子 式 】C20H29NO4 【 分 子 量 】347.45843 |
【开发单位】Kuraray (Originator) 【药理作用】Antiarthritic Drugs, Antiulcer Drugs, GASTROINTESTINAL DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Antiinflammatory Drugs, NF-kappaB (NFKB) Activation Inhibitors |
合成路线1
By condensation of costunolide (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with L-proline (II) by means of Et3N in refluxing ethanol.
| 【1】 Matsuda, H.; et al.; Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa. Tetrahedron 2000, 56, 39, 7763. |
Extended Information