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【结 构 式】 
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【药物名称】SNK-882 【化学名称】2-(2-Oxopyrrolidin-1-yl)-N-(perhydropyrrolizin-7a-ylmethyl)acetamide hydrochloride 【CA登记号】152221-12-0, 108005-79-4 (free base) 【 分 子 式 】C14H24ClN3O2 【 分 子 量 】301.81928 |
【开发单位】Sanwa (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of |
合成路线1
By condensation of 7alpha-(aminomethyl)pyrrolizidine (I) with 2-(2-oxo-pyrrolidin-1-yl)acetic acid methyl ester (II) by heating at 80 C.
| 【1】 Kurono, M.; Hayashi, M.; Suzuki, T.; Miura, K.; Kumagai, Y.; Matsumoto, Y.; Miyano, S.; Sumoto, K. (Sanwa Kagaku Kenkyusho Co., Ltd.); 2-Oxopyrrolidine pharmaceutical compounds, salts and the preparation thereof. EP 0213713; JP 1987022785; US 4678801 . |
| 【2】 Prous, J.; Graul, A.; Castañer, J.; SNK-882. Drugs Fut 1994, 19, 8, 744. |
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