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【结 构 式】 
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【药物名称】XE-991 【化学名称】10,10-Bis(4-pyridylmethyl)anthracen-10(9H)-one 【CA登记号】122955-42-4 【 分 子 式 】C26H20N2O 【 分 子 量 】376.4621 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Acetylcholine Release Enhancers |
合成路线1
The title compound was prepared by alkylation of anthrone (I) with 4-picolyl chloride (II) in the presence of an alkaline hydroxide and a phase-transfer catalyst.
| 【1】 Drummond, S.; Wilkerson, W.W.; Calabrese, J.C.; Earl, R.A.; Teleha, C.A.; Zaczek, R.; Voss, M.E.; Acetylcholine release enhancers related to linopirdine: A structure-activity relationship study. II. Eur J Med Chem 1996, 31, 4, 319. |
| 【2】 Earl, R.A.; Myers, M.J.; Nickolson, V.J. (DuPont Pharmaceuticals Co.); alpha,alpha-Disubstd. aromatics and heteroaromatics as cognition enhancers. EP 0311010; US 5173489 . |
Extended Information