|
【结 构 式】 
|
【药物名称】A-316023 【化学名称】N-Hydroxy-N-[4-[4-[4-(trifluoromethoxy)phenoxy]phenylsulfonylmethyl]tetrahydro-2H-pyran-4-yl]formamide 【CA登记号】 【 分 子 式 】C20H20F3NO7S 【 分 子 量 】475.4441 |
【开发单位】Abbott (Originator) 【药理作用】Oncolytic Drugs, Angiogenesis Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-9 (Gelatinase B) Inhibitors |
合成路线1
Alkylation of ketone (I) with sulfone (II) by means of BuLi yields derivative (III), which is then treated with POCl3 and pyridine to afford compound (IV). Reaction of (IV) with aqueous hydroxylamine (NH2OH) in THF provides derivative (V), which is finally treated with (VI) in THF to furnish the desired compound.
| 【1】 Davidsen, S.K.; Michalides, M.; Stacey, J.R.; et al.; Development of a series of sulfone retrohydroxamates for the inhibition of matrix metalloproteinases. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 54. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31563 | tetrahydro-4H-pyran-4-one | 29943-42-8 | C5H8O2 | 详情 | 详情 |
| (II) | 46241 | methyl(dioxo)[4-[4-(trifluoromethoxy)phenoxy]phenyl]-lambda(6)-sulfane; methyl 4-[4-(trifluoromethoxy)phenoxy]phenyl sulfone | C14H11F3O4S | 详情 | 详情 | |
| (III) | 46242 | 1-[([4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl)methyl]cyclohexanol | C20H21F3O5S | 详情 | 详情 | |
| (IV) | 46243 | 4-[([4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl)methylene]tetrahydro-2H-pyran; tetrahydro-4H-pyran-4-ylidenemethyl 4-[4-(trifluoromethoxy)phenoxy]phenyl sulfone | C19H17F3O5S | 详情 | 详情 | |
| (V) | 46244 | 4-(hydroxyamino)-4-[([4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl)methyl]tetrahydro-2H-pyran; N-[4-[([4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl)methyl]tetrahydro-2H-pyran-4-yl]hydroxylamine | C19H20F3NO6S | 详情 | 详情 | |
| (VI) | 46245 | 2,2,2-trifluoroethyl formate | C3H3F3O2 | 详情 | 详情 |
Extended Information