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【结 构 式】 
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【药物名称】 【化学名称】N-Methyl-2(R)-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-N-(4-nitrobenzyl)-4-oxoazetidine-1-carboxamide 【CA登记号】216960-81-5 【 分 子 式 】C15H17N7O4S 【 分 子 量 】391.41124 |
【开发单位】Bio-Mega (Originator), Boehringer Ingelheim (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antiviral Drugs, Protease Inhibitors |
合成路线1
Silylated 4-oxoazetidine-2-carboxylic acid (I) was converted to the mixed anhydride with isobutyl chloroformate, and then reduced to alcohol (II) with NaBH4. Subsequent Mitsunobu coupling of (II) with mercaptotetrazole (III) provided thioether (IV). Desilylation of (IV) was then achieved by treatment with CsF in MeOH to give (V). Reaction of 4-nitrobenzyl chloride (VI) with methylamine afforded secondary amine (VII). This was reacted with phosgene and diisopropyl ethylamine to produce the carbamoyl chloride (VIII). Finally, condensation of this chloride with azetidinone (V) in the presence of lithium bis(trimethylsilyl)amide furnished the target urea.
| 【1】 Yoakim, C.; Ogilvie, W.W.; Cameron, D.R.; Chabot, C.; Grand-Maitre, C.; Guse, I.; Hache, B.; Kawai, S.; Naud, J.; O'Meara, J.A.; Plante, R.; Deziel, R.; Potent beta-lactam inhibitors of human cytomegalovirus protease. Antivir Chem Chemother 1998, 9, 5, 379. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28418 | (2R)-1-[tert-butyl(dimethyl)silyl]-4-oxo-2-azetidinecarboxylic acid | C10H19NO3Si | 详情 | 详情 | |
| (II) | 28419 | (4R)-1-[tert-butyl(dimethyl)silyl]-4-(hydroxymethyl)-2-azetidinone | C10H21NO2Si | 详情 | 详情 | |
| (III) | 28420 | 5-Mercapto-1-methyl-1H-tetrazole; 1-Methyl-1H-1,2,3,4-tetraazol-5-ylhydrosulfide | 13183-79-4 | C2H4N4S | 详情 | 详情 |
| (IV) | 28421 | (4R)-1-[tert-butyl(dimethyl)silyl]-4-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-2-azetidinone | C12H23N5OSSi | 详情 | 详情 | |
| (V) | 28422 | (4R)-4-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-2-azetidinone | C6H9N5OS | 详情 | 详情 | |
| (VI) | 22580 | 1-(chloromethyl)-4-nitrobenzene | 100-14-1 | C7H6ClNO2 | 详情 | 详情 |
| (VII) | 28426 | N-methyl(4-nitrophenyl)methanamine | C8H10N2O2 | 详情 | 详情 | |
| (VIII) | 28427 | 1-[[(chlorocarbonyl)(methyl)amino]methyl]-4-nitrobenzene | C9H9ClN2O3 | 详情 | 详情 |