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【结 构 式】 
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【药物名称】DU-125530 【化学名称】2-[4-[4-(7-Chloro-2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide 【CA登记号】161612-21-1 (diHCl), 161612-00-6 (monomesylate salt) 【 分 子 式 】C23H26ClN3O5S 【 分 子 量 】491.99777 |
【开发单位】Duphar (Originator), Solvay (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, 5-HT1A Antagonists |
合成路线1
The title compound was prepared by alkylation of 1-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)piperazine (I) with N-(4-bromobutyl)saccharin (II) in the presence of K2CO3 in methylethylketone (MEK).
| 【1】 Regan, J.; Bruno, J.; McGarry, D.; Poli, G.; Hanney, B.; Bower, S.; Travis, J.; Sweeney, D.; Miller, B.; Souness, J.; Djuric, S.; 2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors. Bioorg Med Chem Lett 1998, 8, 19, 2737. |
Extended Information