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【结 构 式】 
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【药物名称】SIB-1553A 【化学名称】(±)-2-[2-(4-Hydroxyphenylsulfanyl)ethyl]-1-methylpyrrolidine hydrochloride 【CA登记号】191611-76-4 (free base) 【 分 子 式 】C13H20ClNOS 【 分 子 量 】273.82745 |
【开发单位】Merck & Co. (Originator) 【药理作用】Alzheimer's Dementia, Treatment of , Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Nicotinic Receptor Agonists |
合成路线1
The condensation of 4-hydroxythiophenol (I) with 2-(2-chloroethyl)-1-methylpyrrolidine (II) in the presence of K2CO3 in DMF afforded the title thioether, which was isolated as the hydrochloride salt.
| 【1】 El-Abdellaoul, H.; Holsenback, H.; Vernier, J.-M.; et al.; 4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): A novel cognitive enhance with selectivity for neuronal nicotinic acetylcholine receptors. J Med Chem 1999, 42, 10, 1684. |
| 【2】 Vernier, J.M.; McDonald, I.A. (SIBIA Neurosciences, Inc.); Novel substd. aryl cpds. useful as modulators of acetylcholine receptors. EP 0874818; JP 2000501080; WO 9719059 . |
Extended Information