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【结 构 式】

【药物名称】Aciclovir elaidate, P-4010

【化学名称】9-[2-[9(E)-Octadecenoyloxy]ethoxymethyl]guanine

【CA登记号】151090-37-8

【 分 子 式 】C26H43N5O4

【 分 子 量 】489.66371

【开发单位】Norsk Hydro (Originator)

【药理作用】Anti-Herpes Simplex Virus Drugs, Anti-Herpes Virus Drugs, ANTIINFECTIVE THERAPY, Antiviral Drugs, Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems

合成路线1

The compound was prepared by condensation of acyclovir (I) with elaidic acid chloride (II) in the presence of pyridine.

1 Dalen, A.; Myhren, F.; Borretzen, B.; Stokke, K.T. (Norsk Hydro AS); Chemical cpds.. GB 2260319; WO 9307163 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28279 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one 59277-89-3 C8H11N5O3 详情 详情
(II) 28280 Oleoyl chloride; (E)-9-Octadecenoyl chloride C18H33ClO 详情 详情
Extended Information