【结 构 式】 |
【药物名称】Nolpitantium besilate, SR-140333B, SR-140333A(chloride), SR-140333(cation) 【化学名称】1-[2-[3-(3,4-Dichlorophenyl)-1-[2-(3-isopropoxyphenyl)acetyl]piperidin-3(S)-yl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane benzenesulfonate 【CA登记号】155418-06-7, 153050-21-6 (cation), 155418-05-6 (chloride) 【 分 子 式 】C43H50Cl2N2O5S 【 分 子 量 】777.85835 |
【开发单位】Sanofi-synthélabo (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, GASTROINTESTINAL DRUGS, Inflammatory Bowel Disease, Agents for, Oncolytic Drugs, RESPIRATORY DRUGS, Tachykinin NK1 Antagonists |
合成路线1
Alkylation of 3,4-dichlorophenylacetonitrile (I) with 2-(tetrahydropyranyloxy)ethyl bromide (II) in the presence of NaH in THF afforded nitrile (III). This was further alkylated with ethyl 3-bromopropionate (IV) using LDA to produce the cyano ester adduct (V). Catalytic hydrogenation of the cyano group of (V) in the presence of Raney-nickel, with concomitant intramolecular cyclization of the intermediate amino ester, gave rise to the piperidinone (VI). This was further reduced to piperidine (VII) using LiAlH4 in THF. After acidic deprotection of the tetrahydropyranyl group of (VII), the racemic amine was resolved by means of tartaric acid to furnish the desired enantiomer (VIII). Acylation of piperidine (VIII) with 3-isopropoxyphenylacetic acid (IX) employing BOP as the coupling reagent yielded amide (X). Conversion of (X) to the mesylate (XI) was carried out by treatment with methanesulfonyl chloride and Et3N. Then, N-alkylation of 4-phenylquinuclidine (XII) with mesylate (XI) produced the corresponding ammonium salt, which was finally subjected to anion exchange of the mesylate for a chloride group by treatment with HCl.
【1】 Emonds-Alt, X.; Gueule, P.; Proietto, V.; Van Broeck, D. (Sanofi-Synthelabo); Quaternary basic amides as tachykinines antagonists. EP 0591040; FR 2696178; JP 1998175976; US 5583134; US 5712288 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 26935 | 2-(3,4-dichlorophenyl)acetonitrile | 3218-49-3 | C8H5Cl2N | 详情 | 详情 |
(II) | 26934 | 2-bromoethyl tetrahydro-2H-pyran-2-yl ether | C7H13BrO2 | 详情 | 详情 | |
(III) | 26936 | 2-(3,4-dichlorophenyl)-4-(tetrahydro-2H-pyran-2-yloxy)butanenitrile | C15H17Cl2NO2 | 详情 | 详情 | |
(IV) | 29132 | ethyl 3-bromopropanoate | 539-74-2 | C5H9BrO2 | 详情 | 详情 |
(V) | 59767 | ethyl 4-cyano-4-(3,4-dichlorophenyl)-6-(tetrahydro-2H-pyran-2-yloxy)hexanoate | C20H25Cl2NO4 | 详情 | 详情 | |
(VI) | 59768 | 5-(3,4-dichlorophenyl)-5-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2-piperidinone | C18H23Cl2NO3 | 详情 | 详情 | |
(VII) | 59769 | 2-[3-(3,4-dichlorophenyl)-3-piperidinyl]ethyl tetrahydro-2H-pyran-2-yl ether; 3-(3,4-dichlorophenyl)-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]piperidine | C18H25Cl2NO2 | 详情 | 详情 | |
(VIII) | 59770 | 2-[(3S)-3-(3,4-dichlorophenyl)piperidinyl]-1-ethanol | C13H17Cl2NO | 详情 | 详情 | |
(IX) | 59771 | 2-(3-isopropoxyphenyl)acetic acid | C11H14O3 | 详情 | 详情 | |
(X) | 59772 | 1-[(3S)-3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)piperidinyl]-2-(3-isopropoxyphenyl)-1-ethanone | C24H29Cl2NO3 | 详情 | 详情 | |
(XI) | 59773 | 2-{(3S)-3-(3,4-dichlorophenyl)-1-[2-(3-isopropoxyphenyl)acetyl]piperidinyl}ethyl methanesulfonate | C25H31Cl2NO5S | 详情 | 详情 | |
(XII) | 59774 | 4-phenyl-1-azabicyclo[2.2.2]octane | C13H17N | 详情 | 详情 |