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【结 构 式】 
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【药物名称】Meclinertant, Reminertant, SR-48692 【化学名称】2-[1-(7-Chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-ylcarboxamido]adamantane-2-carboxylic acid 【CA登记号】146362-70-1 【 分 子 式 】C32H31ClN4O5 【 分 子 量 】587.08067 |
【开发单位】Sanofi-synthélabo (Originator) 【药理作用】GASTROINTESTINAL DRUGS, Inflammatory Bowel Disease, Agents for, Lung Cancer Therapy, Oncolytic Drugs, Prostate Cancer Therapy, Small Cell Lung Cancer Therapy, Carboxypeptidase A Inhibitors, Neurotensin Antagonists |
合成路线1
The condensation of 2',6'-dimethoxyacetophenone (I) with diethyl oxalate (II) by means of sodium methoxide in refluxing methanol gives the dioxobutyrate (III), which is cyclized with 7-chloroquinoline-4-hydrazine (IV) in refluxing acetic acid yielding the pyrazole derivative (V). The hydrolysis of the ester group of (V) with KOH in refluxing methanol/water affords the corresponding carboxylic acid (VI), which is finally treated with SOCl2 in refluxing toluene and condensed with 2-aminoadamantane-2-carboxylic acid.
| 【1】 Boigegrain, R.; Gully, D.; Jeanjean, F.; Molimard, J.-C. (Sanofi-Synthélabo ); Amido-3-pyrazole derivs., process for their preparation and pharmaceutical compsns. containing them. EP 0477049; FR 2665898; JP 1992244065; US 5420141; US 5607958; US 5616592; US 5635526; US 5744491; US 5744493 . |
| 【2】 Maffrand, J.P.; Gully, D.; Boigegrain, R.; Soubrie, P.; Kitabgi, P.; Rostene, W.; Le Fur, G.; Neurotensin receptor agonists and antagonists. Drugs Fut 1993, 18, 12, 1137. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 41280 | 2-amino-2-adamantanecarboxylic acid | C11H17NO2 | 详情 | 详情 | ||
| (I) | 41275 | 1-(2,6-dimethoxyphenyl)-1-ethanone | 2040-04-2 | C10H12O3 | 详情 | 详情 |
| (II) | 17571 | Diethyl oxalate; Ethyl 2-ethoxy-2-oxoacetate | 95-92-1 | C6H10O4 | 详情 | 详情 |
| (III) | 41276 | sodium (Z)-4-(2,6-dimethoxyphenyl)-1-methoxy-1,4-dioxo-2-buten-2-olate | C13H13NaO6 | 详情 | 详情 | |
| (IV) | 41277 | 7-chloro-4-hydrazinoquinoline | 23834-14-2 | C9H8ClN3 | 详情 | 详情 |
| (V) | 41278 | methyl 1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate | C22H18ClN3O4 | 详情 | 详情 | |
| (VI) | 41279 | 1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid | C21H16ClN3O4 | 详情 | 详情 |