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【结 构 式】 
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【药物名称】Pivagabine, Tonerg 【化学名称】4-Pivalamidobutyric acid 【CA登记号】69542-93-4 【 分 子 式 】C9H17NO3 【 分 子 量 】187.24074 |
【开发单位】Angelini (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, CRF Receptor Antagonists |
合成路线1
Pivagabine is prepared by reacting pivaloyl chloride (I) and 4-aminobutyric acid (II) in aqueous sodium hydroxide solution; by adding dilute hydrochloric acid the crude product is isolated and then purified by crystallization from water.
| 【1】 Mezzich, J.E.; Mezzich, A.C.; Fabrega, H.; Adjustment disorder as a marginal or transitional illness category in DSM-III. Arch Gen Psychiatry 1987, 44, 6, 567-72. |
| 【2】 Esposito, G.; Lazzarini, R.; Pivagabine. Drugs Fut 1998, 23, 4, 390. |
Extended Information