【结 构 式】 |
【药物名称】T-138026 【化学名称】2,3,4,5,6-Pentafluoro-N-(3-hydroxy-4-methoxyphenyl)benzenesulfonamide 【CA登记号】195533-52-9, 195533-96-1 (potassium salt), 195533-95-0 (sodium salt) 【 分 子 式 】C13H8F5NO4S 【 分 子 量 】369.26901 |
【开发单位】Tularik (Originator) 【药理作用】ONCOLYTIC DRUGS, Antimitotic Drugs, Microtubule-Stabilizing Agents |
合成路线1
The title sulfonamide was obtained by condensation of pentafluorophenyl sulfonyl chloride (I) with 3-hydroxy-4-methoxyaniline (II) in the presence of pyridine.
【1】 Flygare, J.; Medina, J.; Shan, B.; Clark, D.; Rosen, T. (Tularik Inc.); Pentafluorobenzenesulfonamides and analogs. EP 0939627; WO 9805315 . |
【2】 Rosen, T.; Medina, J.C.; Flygare, J.; Shan, B.; Clark, D. (Tularik Inc.); Pentafluorobenzenesulfonamides and analogs. EP 0896533; JP 2000505459; US 5880151; WO 9730677 . |
Extended Information