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【结 构 式】 
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【药物名称】 【化学名称】Sulfamic acid 5,6,7,8-tetrahydro-2-naphthyl ester 【CA登记号】154532-55-5 【 分 子 式 】C10H13NO3S 【 分 子 量 】227.28401 |
【开发单位】University of Bath (Originator) 【药理作用】Oncolytic Drugs |
合成路线1
By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.
| 【1】 Potter, B.V.L.; Howarth, N.M.; Purohit, A.,; Reed, M.J.; Steroid sulphatase inhibitors: a new endocrine therapy. Drugs Fut 1994, 19, 7, 673. |
| 【2】 Reed, M.J.; Potter, B.V.L.; Purohit, A.,; Howarth, N.M.; Cooper, G.; Duncan, L.J.; Phosphonates and thiophosphonates as sulfate surrogates: Synthesis of estrone 3-methylthiophosphonate a potent inhibitor of estrone sulfatase. Bioorg Med Chem Lett 1993, 3, 2, 313-318. |
Extended Information