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【结 构 式】 
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【药物名称】Amorolfine hydrochloride, MT-861, Ro-14-4767/000(free base), Ro-14-4767/002, Pekiron, Bekiron, Loceryl 【化学名称】(±)-cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine hydrochloride 【CA登记号】78613-35-1 (free base), 67467-83-8 (free base non-specified stereoch.) 【 分 子 式 】C21H36ClNO 【 分 子 量 】353.98017 |
【开发单位】Roche (Originator), Galderma (Not Determined), Kyorin (Licensee), Maruho (Codevelopment), Shiseido (Codevelopment) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY |
合成路线1
By condensation of 3-(4-tert-amylphenyl)propionaldehyde (I) with 2,6-dimethylmorpholine (II) by heating at 100 C in toluene, followed by hydrogenation with H2 over Pd/C in the same solvent.
| 【1】 Pfiffner, A.; Bohnen, K. (Roche); Piperidines morpholines, etc., and fungicidal compsns. Thereof. US 4202894; US 4241058 . |
| 【2】 Blancafort, P.; Castaner, J.; Serradell, M.N.; RO-144,767/002. Drugs Fut 1982, 7, 7, 492. |
Extended Information