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【结 构 式】 
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【药物名称】Balofloxacin dihydrate, Q-35, Baloxin, Neuroquinoron 【化学名称】(±)-1-Cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dihydrate 【CA登记号】127294-70-6 (anhydrous) 【 分 子 式 】C20H28FN3O6 【 分 子 量 】425.46106 |
【开发单位】Chugai (Originator), Choongwae (Licensee), Novartis (Licensee) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Quinolones |
合成路线1
By reaction of 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 3-(methylamino)piperidine (II) by means of triethylamine in refluxing acetonitrile.
| 【1】 Nagano, H.; Yokota, T.; Katoh, Y. (Chugai Seiyaku Co., Ltd.); Novel quinolinecarboxylic acid derivatives. EP 0342675; JP 91095177 . |
| 【2】 Prous, J.; Castaner, J.; Q-35. Drugs Fut 1992, 17, 5, 382. |
Extended Information