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【结 构 式】

【药物名称】Sch-40338

【化学名称】(±)-11-(1-Acetyl-4-piperazinyl)-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine
      (±)-1-Acetyl-4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine

【CA登记号】117796-62-0

【 分 子 式 】C20H22ClN3O

【 分 子 量 】355.87084

【开发单位】Schering-Plough (Originator)

【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Histamine H1 Antagonists, Platelet-Activating Factor (PAF) Antagonists

合成路线1

Benzocycloheptapyridinone (I) was reduced to alcohol (II) with NaBH4 in MeOH. Subsequent treatment of (II) with SOCl2 in toluene gave the tricyclic chloride (III). Finally, alkylation of N-acetyl piperazine (IV) with chloride (III) in the presence of Et3N in boiling THF provided the title compound.

1 Piwinski, J.J.; Wong, J.K.; Green, M.J.; Kaminski, J.J.; Colizzo, F.; Albanese, M.M.; Ganguly, A.K.; Billah, M.M.; Anthes, J.C.; West, R.E. Jr; Dual antagonists of platelet activating factor and histamine 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. Bioorg Med Chem Lett 1998, 8, 24, 3469.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 16504 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one; 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-one 31251-41-9 C14H10ClNO 详情 详情
(II) 17935 8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol C14H12ClNO 详情 详情
(III) 17936 8,11-dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine C14H11Cl2N 详情 详情
(IV) 20674 N-Acetyl piperazine; 1-(1-piperazinyl)-1-ethanone 13889-98-0 C6H12N2O 详情 详情
Extended Information