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【结 构 式】

【药物名称】Ocinaplon, DOV-273547, CL-273547

【化学名称】7-(4-Pyridyl)-3-(pyridin-2-ylcarbonyl)pyrazolo[1,5-a]pyrimidine
      2-Pyridyl[7-(4-pyridyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone

【CA登记号】96604-21-6

【 分 子 式 】C17H11N5O

【 分 子 量 】301.31012

【开发单位】Wyeth Pharmaceuticals (Originator), DOV Pharmaceutical (Licensee)

【药理作用】Anxiolytics, Generalized Anxiety Disorder (GAD), Treatment of, PSYCHOPHARMACOLOGIC DRUGS, GABA(A) Receptor Modulators

合成路线1

Reaction of 4-acetylpyridine (I) with hot dimethylformamide dimethyl acetal (II) gives the enamino ketone (III), which is then condensed with (3-amino-1H-pyrazol-4-yl)(2-pyridyl)methanone (IV) in boiling acetic acid. Intermediate (IV), (3-amino-1H-pyrazol-4-yl)(2-pyrid-yl)methanone, is obtained by condensation of 3-oxo-3-(2-pyridyl)propionitrile (V) with dimethylformamide dimethyl acetal (II) to provide 2-(dimethylaminomethylene)-3-oxo-3-(2-pyridyl)propionitrile (VI), which is finally coupled with aminoguanidine nitrate (VII) by means of 10N NaOH in refluxing EtOH

1 Castaner, J.; Silvestre, J.S.; Chilman-Blair, K.; Ocinaplon. Drugs Fut 2003, 28, 2, 115-120.
2 Tomcufcik, A.S.; Dusza, J.P. (Wyeth); (3-Amino-1H-pyrazol-4-yl)(aryl)methanones. EP 0129846; JP 1985013764; US 4900836 .
3 Dusza, J.P.; Tomcufcik, A.S.; Albright, J.D. (Wyeth); Aryl and heteroaryl 7-(aryl and heteroaryl)-pyrazolo[1,5-a]pyrimidin-3-ylmethanones. DE 3422844; EP 0129847; JP 1985019788 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 59510 4-Acetylpyridine; Methyl 4-pyridyl ketone 1122-54-9 C7H7NO 详情 详情
(II) 11984 N-(Dimethoxymethyl)-N,N-dimethylamine;dimethylformamide dimethylacetal;1,1-dimethoxy-N,N-dimethylmethanamine; Dimethoxy-N,N-dimethylmethanamine; N,N-Dimethylformamide dimethyl acetal 4637-24-5 C5H13NO2 详情 详情
(III) 59511 (E)-3-(dimethylamino)-1-(4-pyridinyl)-2-propen-1-one C10H12N2O 详情 详情
(IV) 59512 (3-amino-1H-pyrazol-4-yl)(2-pyridinyl)methanone C9H8N4O 详情 详情
(V) 59513 3-oxo-3-(2-pyridinyl)propanenitrile C8H6N2O 详情 详情
(VI) 59514 (E)-3-(dimethylamino)-2-(2-pyridinylcarbonyl)-2-propenenitrile C11H11N3O 详情 详情
(VII) 10015 1-Hydrazinecarboximidamide; Hydrazinecarboximidamide 79-17-4 CH6N4 详情 详情
Extended Information