【结 构 式】 |
【药物名称】AA-10026, AA-10025, DDP-225, AA-10021, MCI-225 【化学名称】4-(2-Fluorophenyl)-6-methyl-2-piperazinothieno[2,3-d]pyrimidine hydrochloride hydrate 【CA登记号】135991-48-9, 109348-38-1 (anhydrous), 99487-25-9 (anhydrous free base), 99487-26-0 (HCl salt monoH2O) 【 分 子 式 】C17H20ClFN4OS 【 分 子 量 】382.89055 |
【开发单位】Mitsubishi Chemical (Originator), Mitsubishi Pharma (Originator), Arachnova (Not Determined), Dynogen Pharmaceuticals (Licensee), Taisho (Codevelopment) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antidepressants, GASTROINTESTINAL DRUGS, Irritable Bowel Syndrome, Agents for, Mood Disorders, Treatment of, Non-Opioid Analgesics, PSYCHOPHARMACOLOGIC DRUGS, RENAL-UROLOGIC DRUGS, Urinary Incontinence Therapy, 5-HT Reuptake Inhibitors, 5-HT3 Antagonists, Norepinephrine Reuptake Inhibitors |
合成路线1
By condensation of 2-chloro-4-(2-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine (I) with piperazine (II) in refluxing chloroform or ethanol.
【1】 Ninomiya, K.; Nitta, I.; Tobe, A.; Egawa, S. (Mitsubishi Chem. Ind., Ltd.); Antidepressant and cerebral function improving agents. JP 8700042 . |
【2】 Ninomiya, K.; Nitta, I.; Tobe, A.; Egawa, M.; Kikumoto, R. (Mitsubishi Chemical Corp.); Thieno[2,3-d]pyrimidine derivs. And salts thereof. EP 0150469; JP 1985146891 . |
【3】 Ninomiya, K.; Nitta, K.; Tobe, A.; Egawa, M. (Mitsubishi Chemical Corp.); Antidepressant and cerebral function improving agent. JP 1987000427 . |
【4】 Prous, J.; Castaner, J.; MCI-225. Drugs Fut 1992, 17, 5, 380. |