Furnidipine, Furaldipine, CRE-319, -Drug Synthesis Database

【结构式】

【药物名称】Furnidipine, Furaldipine, CRE-319

【化学名称】(RR,SS)-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester
　　　　　　(±)-2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl (tetrahydro-2-furanyl)methyl diester

【CA登记号】138661-03-7

【分子式】C₂₁H₂₄N₂O₇

【分子量】416.43463

【开发单位】Alter (Originator), Cermol (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Cerebrovascular Diseases, Treatment of, Hypertension, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Calcium Channel Blockers

合成路线1

Synthesis of Furaldipine (EN:163877)

参考文献中间体

【1】 Frank, A.; Karn, H.; Spanig, H. (Abbott GmbH & Co. KG); Production of 1-hydroxyalkyl-5-nitroimidazoles. DE 2359625; FR 2253019; GB 1481349 .
【2】 Frank, A.; Dockner, T.; Karn, H. (Abbott GmbH & Co. KG); Process for the preparation of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity. EP 0150407 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14082	tetrahydro-2-furanylmethyl 3-oxobutanoate		C₉H₁₄O₄	详情	详情
(II)	11370	2-Nitrobenzaldehyde	552-89-6	C₇H₅NO₃	详情	详情
(III)	11791	methyl 3-oxobutanoate; Methyl acetoacetate	105-45-3	C₅H₈O₃	详情	详情
(IV)	14085	tetrahydro-2-furanylmethyl (E)-3-amino-2-butenoate		C₉H₁₅NO₃	详情	详情
(V)	11375	Methyl-2-(2-nitrobenzylidene)acetoacetate; methyl (Z)-2-acetyl-3-(2-nitrophenyl)-2-propenoate	39562-27-1	C₁₂H₁₁NO₅	详情	详情

Extended Information