Eptastigmine tartrate, Heptylstigmine tartrate, L-693487, MF-201, -Drug Synthesis Database

【结构式】

【药物名称】Eptastigmine tartrate, Heptylstigmine tartrate, L-693487, MF-201

【化学名称】(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol heptylcarbamate ester L-tartrate

【CA登记号】101246-68-8 (free base)

【分子式】C₂₅H₃₉N₃O₈

【分子量】509.60488

【开发单位】Mediolanum (Originator)

【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS, Acetylcholinesterase Inhibitors

合成路线1

Condensation of eseroline (I) with heptyl isocyanate yields heptyleserine (II), which is then salified with L-tartaric acid to give the corresponding salt.

参考文献中间体

【1】 Prous, J.; Castaner, J.; HEPTYLSTIGMINE TARTRATE. Drugs Fut 1989, 14, 2, 123.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	20366	heptyl isocyanate; 1-isocyanatoheptane	4747-81-3	C₈H₁₅NO	详情	详情
(I)	20365	(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol		C₁₃H₁₈N₂O	详情	详情
(II)	20367	(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl heptylcarbamate		C₂₁H₃₃N₃O₂	详情	详情

Extended Information