【结 构 式】 |
【药物名称】Tilnoprofen arbamel, Y-23023 【化学名称】(±)-2-(2-Methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid N,N-dimethylcarbamoylmethyl ester 【CA登记号】159098-79-0, 118635-52-2 (undefined stereoch.) 【 分 子 式 】C20H22N2O4 【 分 子 量 】354.40934 |
【开发单位】Japan Tobacco (Originator), Mitsubishi Pharma (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, Non-Steroidal Antiinflammatory Drugs |
合成路线1
By esterification of 2-(2-methyl-5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionic acid (I) with 2-chloro-N,N-dimethylacetamide (II) by means of K2CO3 in hot DMF.
【1】 Oe, T.; Kawasaki, K.; Terasawa, M.; Imayoshi, T. (Japan Tobacco Inc.; Welfide Corporation); Benzopyranopyridine acid ester cpds. and their pharmaceutical uses. EP 0284069; JP 1989025782; US 4808593 . |
【2】 Imayoshi, T.; Terasawa, M.; Kawasaki, K.; Oe, T.; Yamada, I.; Yasunaga, Y.; Goto, K.; Tsuruda, M.; Synthesis, pharmacological activity and biopharmaceutical characteristics of alpha,2-dimethyl-5H-[1]benzopyrano[2,3-d]pyridine-7-acetates. Yakugaku Zasshi 1989, 109, 11, 827. |
【3】 Castaner, J.; Prous, J.; Y-23023. Drugs Fut 1992, 17, 6, 469. |
Extended Information