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【结 构 式】 
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【药物名称】Iproxifene, Miproxifene phosphate, TAT-59 【化学名称】(E)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenol phosphate 【CA登记号】115767-74-3 【 分 子 式 】C29H36NO5P 【 分 子 量 】509.58777 |
【开发单位】Taiho (Originator) 【药理作用】ONCOLYTIC DRUGS, Antiestrogens |
合成路线1
The Grignard condensation of 4'-[2-(dimethylamino)ethoxy]-2-(4-isopropylphenyl)butyrophenone (I) with 4-(2-tetrahydropyranyloxy)phenylmagnesium bromide (II) in refluxing THF gives the triphenylbutanol derivative (III). The dehydration and deprotection of (III) by means of HCl in ethanol yields (E)-4-[1-[4-[2-(dimethylamino)ethoxy)phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenol (IV), which is finally esterified with POCl3 in pyridine and hydrolyzed with NaHCO3 in ice water followed by acidification with concentrated HCl.
| 【1】 Asao, T.; Takeda, S.; Sugimoto, Y.; Toko, T.; Yamada, Y.; Ogawa, K.; Unemi, N. (Taiho Pharmaceutical Co., Ltd.); 1,1,2-Triaryl-1-butene derivs.. AU 8775199; JP 1988503618; US 4897503; WO 8707609 . |
| 【2】 Hoshi, A.; TAT-59. Drugs Fut 1991, 16, 3, 217. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31256 | 1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butanone | C23H31NO2 | 详情 | 详情 | |
| (II) | 31255 | bromo[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]magnesium | C11H13BrMgO2 | 详情 | 详情 | |
| (III) | 31257 | 1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-butanol | C34H45NO4 | 详情 | 详情 | |
| (IV) | 31258 | 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenol | C29H35NO2 | 详情 | 详情 |