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【结 构 式】 
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【药物名称】Azelnidipine, CS-905, RS-9054, Calblock 【化学名称】(±)-2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl] 5-isopropyl diester 【CA登记号】123524-52-7, 116574-11-9 (diHCl salt;non-specified stereoch.), 116573-93-4 (non-specified sterochem.) 【 分 子 式 】C33H34N4O6 【 分 子 量 】582.66213 |
【开发单位】Sankyo (Originator), Ube (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Calcium Channel Blockers |
合成路线1
The esterification of cyanacetic acid (I) with 1-(diphenylmethyl)azetidin-3-ol (II) by means of dicyclohexylcarbodiimide (DCC) in hot THF gives the corresponding cyanacetic ester (III), which is treated with HCl and then with NH3 to afford amidinoacetic acid (1-diphenylmethyl)azetidin-3-yl ester (IV). Finally, this compound is cyclized with 2-(3-nitrobenzylidene)acetoacetic acid isopropyl ester (V) by means of sodium methoxide in refluxing isopropanol.
| 【1】 Koike, H.; Yoshimoto, M.; Nishino, H. (Sankyo Co., Ltd.; Ube Industries, Ltd.); Dihydropyridine derivs., their preparation and their use. EP 0266922; EP 0529702; JP 1988253082; US 4772596 . |
| 【2】 Prous, J.; Castaner, J.; CS-905. Drugs Fut 1990, 15, 7, 1671. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12591 | Cyanoacetic Acid; 2-Cyanoacetic acid | 372-09-8 | C3H3NO2 | 详情 | 详情 |
| (II) | 12592 | 1-Benzhydryl-3-azetidinol; 1-Benzhydryl-3-hydroxyazetidine；1-benzhydrylazetidin-3-ol | 18621-17-5 | C16H17NO | 详情 | 详情 |
| (III) | 12593 | 1-benzhydryl-3-azetidinyl 2-cyanoacetate | C19H18N2O2 | 详情 | 详情 | |
| (IV) | 12594 | 1-benzhydryl-3-azetidinyl 3-amino-3-iminopropanoate | C19H21N3O2 | 详情 | 详情 | |
| (V) | 12595 | isopropyl (Z)-2-acetyl-3-(3-nitrophenyl)-2-propenoate | C14H15NO5 | 详情 | 详情 |