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【结 构 式】 
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【药物名称】Pivalopril, Pivopril, USV 3659(S), RHC 3659(S), REV 3659(S) 【化学名称】(-)-(S)-N-Cyclopentyl-N-[3-(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine 【CA登记号】81045-50-3 【 分 子 式 】C16H27NO4S 【 分 子 量 】329.46189 |
【开发单位】Revlon (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Angiotensin-I Converting Enzyme (ACE) Inhibitors |
合成路线1
The reaction of cyclopentylamine (I) with tertbutyl bromoacetate (II) by means of NH3 in acetonitrile gives N-cyclopentylglycine tert-butyl ester (III), which is condensed with 3-(acetylthio)-2-methylpropionyl chloride (IV) [prepared from the corresponding acid (V) with SOCl2] by means of triethylamine in dioxane to yield the acylated glycine (VI). Deacetylation of (VI) with dry ammonia in methanol affords the mercapto derivative (VII), which is acylated with pivaloyl chloride (VIII) in the usual way giving the corresponding thio ester (IX). Finally, this compound is hydrolyzed partially with trimethylsilyl iodide in methylene chloride.
| 【1】 Suh, J.T.; et al.; Angiotensin-converting enzyme inhibitors. New orraly active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives. J Med Chem 1985, 28, 1, 57-66. |
| 【2】 Castaner, J.; Serradell, M.N.; Pivopril. Drugs Fut 1986, 11, 2, 116. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28850 | cyclopentanamine | 1003-03-8 | C5H11N | 详情 | 详情 |
| (II) | 17430 | 2-Bromoacetic acid tert-butyl ester; tert-butyl 2-bromoacetate; tert-Butyl bromoacetate | 5292-43-3 | C6H11BrO2 | 详情 | 详情 |
| (III) | 28851 | tert-butyl 2-(cyclopentylamino)acetate | C11H21NO2 | 详情 | 详情 | |
| (IV) | 28852 | (2R)-3-Acetylthio-2-methylpropionyl chloride;L-3-(Acetylthio)-2-methylpropanoyl chloride ;S-[(2R)-3-chloro-2-methyl-3-oxopropyl] ethanethioate | 74345-73-6 | C6H9ClO2S | 详情 | 详情 |
| (V) | 28853 | (2R)-3-(acetylsulfanyl)-2-methylpropionic acid;(R)-3-(acetylthio)-2-methylpropanoic acid | 74431-52-0 | C6H10O3S | 详情 | 详情 |
| (VI) | 28854 | tert-butyl 2-[[(2S)-3-(acetylsulfanyl)-2-methylpropanoyl](cyclopentyl)amino]acetate | C17H29NO4S | 详情 | 详情 | |
| (VII) | 28855 | tert-butyl 2-[cyclopentyl[(2S)-2-methyl-3-sulfanylpropanoyl]amino]acetate | C15H27NO3S | 详情 | 详情 | |
| (VIII) | 13597 | 2,2-Dimethylpropanoyl chloride; Pivaloyl chloride | 3282-30-2 | C5H9ClO | 详情 | 详情 |
| (IX) | 28856 | tert-butyl 2-(cyclopentyl[(2S)-3-[(2,2-dimethylpropanoyl)sulfanyl]-2-methylpropanoyl]amino)acetate | C20H35NO4S | 详情 | 详情 |