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【结 构 式】

【药物名称】Norfloxacin succinil, Eminor

【化学名称】7-[4-(3-Carboxypropionyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

【CA登记号】100587-52-8, 100587-53-9 (diNa salt)

【 分 子 式 】C20H22FN3O6

【 分 子 量 】419.41324

【开发单位】Farmades (Originator)

【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Quinolones

合成路线1

By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane. Acetic acid can also be used as solvent in the acylation.

1 Di Schiena, M. (Farmades); Cpds. having antibacterial activity, process for their preparation and pharmaceutical compsns. Containing them. EP 0155006 .
2 Prous, J.; Castaner, J.; NORFLOXACIN SUCCINIL. Drugs Fut 1990, 15, 6, 578.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11290 1-Ethyl-6-fluoro-4-oxo-7-piperazino-1,4-dihydro-3-quinolinecarboxylic acid; Norfloxacin 70458-96-7 C16H18FN3O3 详情 详情
(II) 11291 Dihydro-2,5-furandione; Succinic anhydride 108-30-5 C4H4O3 详情 详情
Extended Information