【结 构 式】 |
【药物名称】Norfloxacin succinil, Eminor 【化学名称】7-[4-(3-Carboxypropionyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 【CA登记号】100587-52-8, 100587-53-9 (diNa salt) 【 分 子 式 】C20H22FN3O6 【 分 子 量 】419.41324 |
【开发单位】Farmades (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Quinolones |
合成路线1
By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane. Acetic acid can also be used as solvent in the acylation.
【1】 Di Schiena, M. (Farmades); Cpds. having antibacterial activity, process for their preparation and pharmaceutical compsns. Containing them. EP 0155006 . |
【2】 Prous, J.; Castaner, J.; NORFLOXACIN SUCCINIL. Drugs Fut 1990, 15, 6, 578. |
Extended Information