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【结 构 式】 
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【药物名称】PFS-1144, EO-122 【化学名称】N-(2,6-Dimethylphenyl)quinuclidine-3-amine hydrochloride 【CA登记号】23581-62-6 【 分 子 式 】C16H23ClN2O 【 分 子 量 】294.82751 |
【开发单位】Purdue Pharma (Originator) 【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS |
合成路线1
The synthesis of EO 122 starts from quinuclidine-3-carboxylic acid (I), which is converted to the acid chloride (II) by oxalyl chloride. The addition of 2,6-dimethylaniline (III) to the acid chloride yields EO-122.
| 【1】 Kaplinsky, E.; Bruckstein, R.; Kariv, E.; Oppenheimer, E.; Cohen, S.; A preclinical study of EO-122, a new lidocaine-lik. Angiology 1980, 31, 410. |
| 【2】 Renk, E.; Grob, C.A.; Studie in the quinudidine line. 3-Quinudialine-car. Helv Chim Acta 1954, 37, 1689. |
| 【3】 Oppenheimer, E.; Binah, O.; EO-122. Drugs Fut 1988, 13, 8, 724. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 29841 | Oxalyl chloride; 2-Chloro-2-oxoacetyl chloride | 79-37-8 | C2Cl2O2 | 详情 | 详情 | |
| (I) | 20290 | 3-quinuclidinecarboxylic acid | C8H13NO2 | 详情 | 详情 | |
| (II) | 20291 | 3-quinuclidinecarbonyl chloride | C8H12ClNO | 详情 | 详情 | |
| (III) | 17527 | 2,6-Xylidine; 2,6-Dimethylaniline; 2,6-Dimethylphenylamine | 87-62-7 | C8H11N | 详情 | 详情 |
Extended Information