SK&F-100330A, -Drug Synthesis Database

【结构式】

【药物名称】SK&F-100330A

【化学名称】N-(4,4-Diphenyl-3-butenyl)guvacine hydrochloride
　　　　　　1-(4,4-Diphenyl-3-butenyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride

【CA登记号】85375-88-8

【分子式】C₂₂H₂₄ClNO₂

【分子量】369.89508

【开发单位】GlaxoSmithKline (Originator)

【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS

合成路线1

The methyl ester of 1,2,5,6-tetrahydro-3-pyridinecarboxylate (guvacine) (II) is N-alkylated with 4,4-diphenyl-3-butenyl bromide (I). The methyl ester of N-(4,4-diphenyl-3-butenyl)guvacine thus obtained is then hydrolvzed with HCl to yield the hydrochloride of the free acid.

参考文献中间体

【1】 Fe, A.; et al.; Orally active and potent inhibitors of gamma-aminobutyric acid uptake. J Med Chem 1985, 28, 5, 653.
【2】 Loscher, W.; SK&F-100330-A. Drugs Fut 1986, 11, 1, 39.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	24116	1-(4-bromo-1-phenyl-1-butenyl)benzene	C₁₆H₁₅Br	详情	详情
(II)	24117	methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate	C₇H₁₁NO₂	详情	详情
(III)	24118	methyl 1-(4,4-diphenyl-3-butenyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylate	C₂₃H₂₅NO₂	详情	详情

Extended Information