Riodipine, PP-1466, Foridone, Phoridone, -Drug Synthesis Database

【结构式】

【药物名称】Riodipine, PP-1466, Foridone, Phoridone

【化学名称】4-[2-(Difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid dimethyl ester
　　　　　　Dimethyl 4-[o-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethy-3,5-pyridinedicarboxylate
　　　　　　2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydropyridine

【CA登记号】71653-63-9

【分子式】C₁₈H₁₉F₂NO₅

【分子量】367.35263

【开发单位】Latvian Institute of Organic Synthesis (Originator), Nikken Chemicals (Originator)

【药理作用】Angina pectoris, Treatment of, CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Calcium Channel Blockers

合成路线1

By cyclization of 2-(difluoromethoxy)benzaldehyde (I) with methyl acetoacetate (II) and refluxing aqueous concentrated ammonia.

参考文献中间体

【1】 Dubur, G.Y.; 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)1,4-dihydropyridine. DE 2900537; FR 2414501; GB 2013186; JP 79122280; US 4219653 .
【2】 Serradell, M.N.; Castaner, J.; Riodipine. Drugs Fut 1985, 10, 11, 922.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	29790	2-(difluoromethoxy)benzaldehyde	71653-64-0	C₈H₆F₂O₂	详情	详情
(II)	11791	methyl 3-oxobutanoate; Methyl acetoacetate	105-45-3	C₅H₈O₃	详情	详情

Extended Information