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【结 构 式】 
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【药物名称】DPI-201106 【化学名称】4-[3-[4-(Diphenylmethyl)piperazin-1-yl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile 【CA登记号】78573-03-2, 78573-15-6 (methanesulfonate), 78573-14-5 (propanedioate) 【 分 子 式 】C29H30N4O2 【 分 子 量 】466.58805 |
【开发单位】Novartis (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy |
合成路线1
By condesation of 4-(2,3-epoxypropoxy)-1H-indole-2-carbonitrile (I) with 1-(diphenylmethyl)piperazine (II).
| 【1】 Belleau, B.; Nguyen-Ba, N. (BioChem Pharma Inc.); Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B. EP 0494119; JP 1994507150; US 5532246; WO 9211852 . |
| 【2】 Koch, H.; DPI-201106. Drugs Fut 1985, 10, 12, 979. |
Extended Information