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【结 构 式】 
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【药物名称】AN-9, Pivanex 【化学名称】Butanoic acid pivaloyloxymethyl ester 【CA登记号】122110-53-6 【 分 子 式 】C10H18O4 【 分 子 量 】202.25256 |
【开发单位】Bar-Ilan University (Originator), Titan (Licensee) 【药理作用】IMMUNOMODULATING AGENTS, Immunomodulators, Liver Cancer Therapy, Lung Cancer Therapy, Non-Small Cell Lung Cancer Therapy, Oncolytic Drugs, Apoptosis Inducers, Histone Deacetylase (HDAC) Inhibitors |
合成路线1
The title butyric acid prodrug was prepared by condensation of butyric acid (I) with chloromethyl pivalate (II) in the presence of Et3N in acetone.
| 【1】 Nudelman, A.; Shaklai, M.; Rephaeli, A. (Bar-Ilan University); Biologically active carboxylic acid esters. EP 0302349; JP 1998152436; JP 1998152454 . |
| 【2】 Nudelman, A.; et al.; Novel anticancer prodrugs of butyric acid. 2. J Med Chem 1992, 35, 4, 687. |
Extended Information