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【结 构 式】

【药物名称】Alitretinoin, BAL-4079

【化学名称】9-cis-Retinoic acid
      (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid

【CA登记号】5300-03-8

【 分 子 式 】C20H28O2

【 分 子 量 】300.4351

【开发单位】Basilea Pharmaceutica AG (CH).

【药理作用】Alitretinoin. Retinoid, Treatment of chronic hand dermatitis

合成路线1

The photoisomerization of trans-retinoic acid (I) in hot acetonitrile using a tungsten lamp produces an equilibrium mixture containing the target 9-cis-retinoic acid, which can be isolated by recrystallization from EtOH (1, 2). A number of methods are based on the preparation of the ethyl (IIa) and methyl (IIb) esters of alitretinoin, which can be hydrolyzed to the corresponding carboxylic acid under alkaline conditions (3-11). In an alternative procedure, Wittig reaction of the 9-cis-phosphonium salts (IIIa) or (IIIb) (which can be isolated as byproducts in the production of the analogous all-trans derivatives) with 3-methyl-4-oxocrotonate esters (IVa/b), with concomitant ester group hydrolysis in the reaction medium, provides directly the target 9-cis-retinoic acid (12, 13). A different strategy consists of the condensation of the β-ionylideneacetaldehyde (V) with dimethyl β-methylglutaconate (VI) under strongly alkaline conditions to provide the diacid adduct (VII), which is mono-decarboxylated to 9,13-di-cis-retinoic acid (VIII) in the presence of copper acetate in hot 2,4-lutidine. Subsequent isomerization of (VIII) to the title 9-cis-tretinoin is accomplished by light irradiation in the presence of a trace of iodine (14). In a further synthetic route to the title compound, rearrangement of the propargylic alcohol (IX) with phenylsulfenyl chloride and triethylamine results in the conjugated sulfoxide (X) which, after desulfuration with t-BuLi and MeLi and desilylation with TBAF, gives 9-cis-retinol (XI). Finally, oxidation of alcohol (XI) utilizing MnO2 and AgO in MeOH furnishes the target carboxylic acid (15). Scheme 1.

1 Coe, J.W. (Pfizer, Inc.). Method for the preparation of 9-cis retinoic acid. WO 9422818.
2 Coe, J.W., O’Connell, T. Convenient preparation of 9-cis-retinoic acid. Bioorg Med Chem Lett 1994, 4(2): 349-50.
3 Boehm, M.F., McClurg, M.R., Pathirana, C. et al. Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. J Med Chem 1994, 37(3): 408-14.
4 Bennani, Y.L. An efficient and stereoselective synthesis of 9-cis-retinoic acid. J Org Chem 1996, 61(10): 3542-4.
5 Wada, A., Hiraishi, S., Takamura, N., Date, T., Aoe, K., Ito, M. A novel method for a stereoselective synthesis of trisubstituted olefin using tricarbonyliron complex: A highly stereoselective synthesis of (all-E)- and (9Z)-retinoic acids. J Org Chem 1997, 62(13): 4343-8.
6 Wada, A., Fukunaga, K., Ito, M., Mizuguchi, Y., Nakagawa, K., Okano, T. Preparation and biological activity of 13-substituted retinoic acids. Bioorg Med Chem 2004, 12(14): 3931-42.
7 Pazos, Y., de Lera, A.R. Stereoselective synthesis of 9-cis-retinoic acid by Suzuki reaction. Tetrahedron Lett 1999, 40(47): 8287-90.
8 Pazos, Y., Iglesias, B., de Lera, A.R. The Suzuki coupling reaction in the stereocontrolled synthesis of 9-cis-retinoic acid and its ring-demethylated analogues. J Org Chem 2001, 66(25): 8483-9.
9 Bennani, Y.L., Boehm, M.F. Synthesis of high specific activity 2,3- and 3,4-[3H]2-9-cis-retinoic acid. J Org Chem 1995, 60(5): 1195-200.
10 Tadikonda, P.K., Lacy, J.M., Rigdon, M.G., DeLuca, H.F. Synthesis of 9-cis-retinoic acid and C-20-[3H3C]-9-cis-retinoic acid with high specific activity. J Label Comp Radiopharm 1997, 34(1): 1-10.
11 DeLuca, H.F., Tadikonda, P.K. (Wisconsin Alumni Res. Found.). Method of synthesis of retinoic acid. US 5808120.
12 John, M., Paust, J. (BASF AG). Preparation of 9-(Z)-retinoic acid. US 5504230.
13 Soukup, M., Thomessen, R. (F. Hoffmann-la Roche AG). Process for the production of 9-cis retinoic acid. CA 2520018, EP 1615879, JP 2006522757, US 2004235951, US 7015353, WO 2004089887.
14 Robeson, C.D., Cawley, J.D., Weisler, L., Stern, M.H., Eddinger, C.C., Chechak, A.J. Chemistry of vitamin A. XXIV. The synthesis of geometric isomers of vitamin A via methyl beta-methylglutaconate. J Am Chem Soc 1955, 77(15): 4111.
15 de Lera, A.R., Castro, A., Torrado, A., Lopez, S. Stereoselective isomerization of 10-arylsulfenate-11,12-dehydroretinoids to 9-cis-retinoids. Tetrahedron Lett 1998, 39(25): 4575-8.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(Iia) 65476 9-cis-Retinoic acid ethyl ester; Ethyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate   C22H32O2 详情 详情
(IIb) 65477 9-cis-Retinoic acid methyl ester; Methyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate   C21H30O2 详情 详情
(IIIa) 65478 (E,E)-[3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexen-1-yl)Penta-2,4-Dienyl]Triphenylphosphonium Chloride 53282-28-3 C33H38ClP 详情 详情
(IIIb) 65479 (E,E)-[3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexen-1-yl)Penta-2,4-Dienyl]Triphenylphosphonium bisulfate   C33H38P.HSO4 详情 详情
(Iva) 40061 ethyl (E)-3-methyl-4-oxo-2-butenoate 62054-49-3 C7H10O3 详情 详情
(Ivb) 65480 Methyl (E)-3-methyl-4-oxocrotonate   C6H8O3 详情 详情
(I) 32679 (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; Retinoic acid 302-79-4 C20H28O2 详情 详情
(V) 65481 (2E,4E)-3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexenyl)Penta-2,4-Dienal 1209-68-3 C15H22O 详情 详情
(VI) 65482 Dimethyl 3-methylpent-2-enedioate 52313-87-8 C8H12O4 详情 详情
(VII) 65483     C21H28O4 详情 详情
(VIII) 65484 9-cis-Retinoic acid; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid 5300-03-8 C20H28O2 详情 详情
(IX) 65485     C27H44O2Si 详情 详情
(X) 65486     C32H52O2SSi 详情 详情
(XI) 65487 9-cis Retinol; 9-Cis-Retinol; Retinol, 9-Cis-; 13-Cis-Retinol 22737-97-9 C20H30O 详情 详情

合成路线2

Alitretinoin esters (IIa) and (IIb) can be prepared by a variety of methods. Horner-Emmons reaction of either the ionylideneacetaldehyde (V) (3, 4) or its tricarbonyl iron complex (XII) (5) with diethyl 3-(ethoxycarbonyl)-2-methylprop-2-enylphosphonate (XIII), optionally followed by decomplexation using CuCl2 in EtOH, provides alitretinoin ethyl ester (IIa). Alternatively, Wittig reaction of aldehyde (V) with iodomethylenetriphenylphosphorane, followed by in situ elimination of HI using an excess of sodium hexamethyldisilazide, and then addition of lithium butyl(tributylstannyl)cyanocuprate to the obtained terminal acetylene, leads to the unstable vinyl stannane (XIV). Subsequent Stille coupling of crude stannane (XIV) with the vinyl triflate (XV) (derived from ethyl acetoacetate) furnishes the target 9-cis-retinoate (IIa) (6). In a different route, the addition of lithium butyl(tributylstannyl)-cyanocuprate (generated from Bu3SnH, BuLi and CuCN) to (Z)-3-methyl-2-penten-4-yn-1-ol (XVI) and MnO2 oxidation of the allyl alcohol function results in the stannyl dienal (XVII). Subsequent Horner-Emmons reaction of aldehyde (XVII) with phosphonate (XIII) followed by iododestannylation of the obtained adduct furnishes the tetraenyl iodide (XVIII). 2,2,6-Trimethylcyclohexanone (XIX) is reacted with hydrazine hydrate and Et3N in boiling EtOH to produce the corresponding hydrazone, which is converted to vinyl iodide upon treatment with iodine and DBN. Metalation of the vinyl iodide with t-BuLi followed by trapping with trimethyl borate generates an unstable intermediate, assumed to be the boronic ester (XX). Then, Suzuki coupling between the in situ-generated boronate (XX) and freshly prepared tetraenyl iodide (XVIII) provides the target cis-retinoate (IIa) in satisfactory yields (7, 8). Two related synthetic strategies, useful for introducing tritium labeling onto the cyclohexenyl ring of (II), are based on the catalytic hydrogenation of the conjugated cyclohexadiene compound (XXIa) or its nonconjugated analogue (XXIb) in the presence of Rh(PPh3)3Cl (9). Compound (IIb), along with some labeled derivatives, can be prepared by the following route. Condensation of 2,2,6-trimethylcyclohexanone (XIX) with the bromomagnesium acetylide of (Z)-3-methyl-2-penten-4-yn-1-ol (XVI) affords the propargylic alcohol adduct (XXII). After reduction of the triple bond of (XXII) with LiAlH4, oxidation of the primary alcohol group using MnO2 in dry CH2Cl2 yields the hydroxy dienal (XXIII). Wittig olefination of aldehyde (XXIII) with (methoxycarbonylmethylene)triphenylphosphorane followed by smooth dehydration of the tertiary alcohol with 80% formic acid in hexane then leads to the tetraenoate ester (XXIV). After reduction of ester (XXIV) with DIBALH and reoxidation of the obtained alcohol to aldehyde with MnO2, the addition of methylmagnesium bromide results in the secondary alcohol (XXV). The deuterium and tritium analogues of (XXV) can be similarly obtained by using the corresponding labeled Grignard reagents. Subsequent oxidation of (XXV) with MnO2 followed by condensation of the resulting methyl ketone with methyl diethylphosphonoacetate leads to the 9-cis-methylretinoate (IIb) (10, 11). Scheme 2.

3 Boehm, M.F., McClurg, M.R., Pathirana, C. et al. Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. J Med Chem 1994, 37(3): 408-14.
4 Bennani, Y.L. An efficient and stereoselective synthesis of 9-cis-retinoic acid. J Org Chem 1996, 61(10): 3542-4.
5 Wada, A., Hiraishi, S., Takamura, N., Date, T., Aoe, K., Ito, M. A novel method for a stereoselective synthesis of trisubstituted olefin using tricarbonyliron complex: A highly stereoselective synthesis of (all-E)- and (9Z)-retinoic acids. J Org Chem 1997, 62(13): 4343-8.
6 Wada, A., Fukunaga, K., Ito, M., Mizuguchi, Y., Nakagawa, K., Okano, T. Preparation and biological activity of 13-substituted retinoic acids. Bioorg Med Chem 2004, 12(14): 3931-42.
7 Pazos, Y., de Lera, A.R. Stereoselective synthesis of 9-cis-retinoic acid by Suzuki reaction. Tetrahedron Lett 1999, 40(47): 8287-90.
8 Pazos, Y., Iglesias, B., de Lera, A.R. The Suzuki coupling reaction in the stereocontrolled synthesis of 9-cis-retinoic acid and its ring-demethylated analogues. J Org Chem 2001, 66(25): 8483-9.
9 Bennani, Y.L., Boehm, M.F. Synthesis of high specific activity 2,3- and 3,4-[3H]2-9-cis-retinoic acid. J Org Chem 1995, 60(5): 1195-200.
10 Tadikonda, P.K., Lacy, J.M., Rigdon, M.G., DeLuca, H.F. Synthesis of 9-cis-retinoic acid and C-20-[3H3C]-9-cis-retinoic acid with high specific activity. J Label Comp Radiopharm 1997, 34(1): 1-10.
11 DeLuca, H.F., Tadikonda, P.K. (Wisconsin Alumni Res. Found.). Method of synthesis of retinoic acid. US 5808120.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(Iia) 65476 9-cis-Retinoic acid ethyl ester; Ethyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate   C22H32O2 详情 详情
(IIb) 65477 9-cis-Retinoic acid methyl ester; Methyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate   C21H30O2 详情 详情
(V) 65481 (2E,4E)-3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexenyl)Penta-2,4-Dienal 1209-68-3 C15H22O 详情 详情
(XII) 65488 complex of (2E,4E)-3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexenyl)Penta-2,4-Dienal with Fe(CO)3   C15H22O.Fe(CO)3 详情 详情
(XIII) 44704 ethyl (E)-4-(diethoxyphosphoryl)-3-methyl-2-butenoate 41891-54-7 C11H21O5P 详情 详情
(XIV) 65489     C28H50Sn 详情 详情
(XV) 65490     C7H9F3O5S 详情 详情
(XVI) 65491 (Z)-3-methylpent-2-en-4-yn-1-ol 105-29-3 C6H8O 详情 详情
(XVII) 65492     C18H34OSn 详情 详情
(XVIII) 65493     C13H17IO2 详情 详情
(XIX) 65494 2,2,6-Trimethylcyclohexanone   C9H15O 详情 详情
(XX) 65495     C11H21BO2 详情 详情
(XXI) 65496     C22H30O2 详情 详情
(XXII) 65497     C15H24O2 详情 详情
(XXIII) 65498     C15H24O2 详情 详情
(XXIV) 65499     C18H26O2 详情 详情
(XXV) 65500     C18H28O 详情 详情

合成路线3

The aldehyde intermediates (V) and (XII) are produced starting from β-ionone (XXVI) by several different methods. The lithium enolate of ketone (XXVI) is acylated with diethyl chlorophosphate to produce an enol phosphate intermediate, which undergoes regioselective β-elimination in the presence of LDA to furnish acetylene (XXVII). Deprotonation of (XXVII) with butyl lithium followed by treatment with phenyl cyanate gives nitrile (XXVIII), which undergoes conjugate addition of dimethyl cuprate in cold THF to afford the cis-trienenitrile (XXIX). Subsequent reduction of nitrile (XXIX) using DIBALH in hexane at –78 °C provides the target aldehyde (V) as the major isomer (4). Alternatively, Reformatsky reaction of β-ionone (XXVI) with the organo zinc reagent derived from ethyl bromoacetate followed by acidic dehydration produces a mixture of cis- and trans-ionylideneacetates (XXX), which, after saponification to the corresponding carboxylic acids, are separated by fractional crystallization from acetonitrile. The desired cis-isomer (XXXI) is then esterified by treatment with iodomethane and potassium carbonate under nonisomerizing conditions to furnish the cis-methyl ester (XXXIIa) (14). Reduction of ester (XXXIIa) with LiAlH4 in cold THF followed by re-oxidation of the resulting alcohol with MnO2 in CH2Cl2 affords aldehyde (V) (3, 14). The analogous tritium-labeled intermediate is similarly obtained utilizing [3H]-LiAlH4 in the reduction step (3). The tricarbonyliron complex of β-ionone (XXXIII) can be conveniently prepared by treatment of (XXVI) with dodecacarbonyltriiron(0) in boiling benzene. Condensation of (XXXIII) with the lithium enolate of ethyl acetate in cold THF gives the hydroxy ester adduct (XXXIV), which is dehydrated by means of SOCl2 in pyridine to produce the (9Z)-conjugated ester (XXXV) as the major isomer. Reduction of ester (XXXV) with DIBALH in Et2O at –45 °C yields the trienol derivative (XXXVI), which is converted to aldehyde (XII) without decomplexation by mild oxidation of the corresponding bromomagnesium alkoxide with azodicarbonyldipiperidine under Mukaiyama’s conditions. Alternatively, decomplexation of (XXXV) with CuCl2 provides the ethyl ester (XXXIIb), which is reduced to aldehyde (V) following known procedures (5). Scheme 3.

3 Boehm, M.F., McClurg, M.R., Pathirana, C. et al. Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. J Med Chem 1994, 37(3): 408-14.
4 Bennani, Y.L. An efficient and stereoselective synthesis of 9-cis-retinoic acid. J Org Chem 1996, 61(10): 3542-4.
5 Wada, A., Hiraishi, S., Takamura, N., Date, T., Aoe, K., Ito, M. A novel method for a stereoselective synthesis of trisubstituted olefin using tricarbonyliron complex: A highly stereoselective synthesis of (all-E)- and (9Z)-retinoic acids. J Org Chem 1997, 62(13): 4343-8.
14 Robeson, C.D., Cawley, J.D., Weisler, L., Stern, M.H., Eddinger, C.C., Chechak, A.J. Chemistry of vitamin A. XXIV. The synthesis of geometric isomers of vitamin A via methyl beta-methylglutaconate. J Am Chem Soc 1955, 77(15): 4111.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XXXIIa) 65506     C16H24O2 详情 详情
(XXXIIb) 65507     C17H26O2 详情 详情
(V) 65481 (2E,4E)-3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexenyl)Penta-2,4-Dienal 1209-68-3 C15H22O 详情 详情
(XII) 65488 complex of (2E,4E)-3-Methyl-5-(2,6,6-Trimethyl-1-Cyclohexenyl)Penta-2,4-Dienal with Fe(CO)3   C15H22O.Fe(CO)3 详情 详情
(XXVI) 39584 (E)-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one 14901-07-6 C13H20O 详情 详情
(XXVII) 65501   73395-75-2 C13H18 详情 详情
(XXVIII) 65502     C14H17N 详情 详情
(XXIX) 65503     C15H21N 详情 详情
(XXX) 65504 (2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1-cyclohexenyl)penta-2,4-dienoic acid ethyl ester 5452-61-9 C17H26O2 详情 详情
(XXXI) 65505     C15H22O2 详情 详情
(XXXIII) 65508     C13H20O.Fe(CO)3 详情 详情
(XXXIV) 65509     C17H28O3.Fe(CO)3 详情 详情
(XXXV) 65510     C17H26O2.Fe(CO)3 详情 详情
(XXXVI) 65511     C15H24O.Fe(CO)3 详情 详情

合成路线4

The dehydro precursors (XXIa) and (XXIb) are prepared by the following sequences. Allylic bromination of β-cyclocitral (XXXVII) with N-bromosuccinimide in cold CH2Cl2 in the presence of CaO and NaHCO3 followed by elimination of HBr in boiling collidine gives α-safranal (XXXVIII). Subsequent cyclization of aldehyde (XXXVIII) with the lithium carbanion derived from ethyl 3,3-dimethylacrylate (XXXIX) in cold THF provides lactone (XLa). The analogous lactone containing an unconjugated cyclohexadiene ring (XLb) is obtained by MichaelWittig tandem reaction of ethyl 2-isopropylideneacetoacetate (XLI) with the phosphorous ylide derived from allyltriphenylphosphonium chloride (XLII) to produce the cyclic ester (XLIII). Subsequent LiAlH4 reduction of ester (XLIII) followed by Swern oxidation gives aldehyde (XLIV). After isomerization of aldehyde (XLIV) upon treatment with catalytic DBU in CH2Cl2 at room temperature, the isomeric cyclohexadienal (XLV) is condensed with ethyl 3,3-dimethylacrylate (XXXIX) as above to furnish lactone (XLb). Reduction of either lactone (XLa) or (XLb) with DIBALH followed by acid-catalyzed ring opening of the resulting lactols leads to the respective tetraenic aldehydes (XLVIa) and (XLVIb), which undergo Horner-Emmons olefination with diethyl 3-(ethoxycarbonyl)-2-methylprop-2-enylphosphonate (XIII) to furnish the corresponding esters (XXIa) and (XXIb) (9). Scheme 4.

9 Bennani, Y.L., Boehm, M.F. Synthesis of high specific activity 2,3- and 3,4-[3H]2-9-cis-retinoic acid. J Org Chem 1995, 60(5): 1195-200.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(Xla) 65514     C15H20O2 详情 详情
(XLb) 65515     C15H20O2 详情 详情
(XLVIa) 65521     C15H20O 详情 详情
(XLVIb) 65522     C15H20O 详情 详情
(XIII) 44704 ethyl (E)-4-(diethoxyphosphoryl)-3-methyl-2-butenoate 41891-54-7 C11H21O5P 详情 详情
(XXI) 65496     C22H30O2 详情 详情
(XXXVII) 65512 beta-Cyclocitral; 2,6,6-Trimethyl-1-Cyclohexenecarboxaldehyde; Ai3-37227 432-25-7 C10H16O 详情 详情
(XXXVIII) 65513 2,6,6-Trimethyl-1,3-Cyclohexadiene-1-Carboxaldehyde 116-26-7 C10H14O 详情 详情
(XXXIX) 24113 methyl 3-methyl-2-butenoate; Methyl 3,3-dimethylacrylate 924-50-5 C6H10O2 详情 详情
(XLI) 65516 ethyl 2-isopropylideneacetoacetate   C9H14O3 详情 详情
(XLII) 65517 allyltriphenylphosphonium chloride   C21H20ClP 详情 详情
(XLIII) 65518     C12H18O2 详情 详情
(XLIV) 65519     C10H13O 详情 详情
(XLV) 65520     C10H13O 详情 详情

合成路线5

The monosilylated unsaturated diol (IX) can be synhesized as follows. Darzen’s condensation of β-ionone (XXVI) with ethyl chloroacetate (XLVII) in the presence of sodium methoxide affords the glycidic ester (XLVIII), which undergoes hydrolysis and decarboxylation to aldehyde (XLIX) upon treatment with methanolic NaOH (16). Protection of (E)-3-methyl-2-penten-4-yn-1-ol (L) with ert-butyldimethylsilyl chloride in the presence of imidazole and DMAP provides the corresponding silyl ether (LI) (17), which, after deprotonation with BuLi at low temperature, is condensed with aldehyde (XLIX) to provide the arget propargylic alcohol (IX) (18). Scheme 5.

16 von Isler, O., Huber, W., Ronco, A., Kofler, M. Synthese des vitamin A. Helv Chim Acta 1947, 30(6): 1911-27.
17 Marshall, J.A., Tang, Y. Enantioselective synthesis of carbohydrate precursors via 1,2:2,3-bis-epoxide intermediates. J Org Chem 1994, 59(6): 1457-64.
18 Lopez, S., Rodriguez, J., Rey, J.G., de Lera, A.R. Structural effects affecting the thermal electrocyclic ring closure of vinylallenes to alkylidenecyclobutenes. J Am Chem Soc 1996, 18(8): 1881-91.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
Extended Information