【结 构 式】 |
【药物名称】Besifloxacin Hydrochloride, SS-734, BOL-303224-A, ISV-403 【化学名称】7-[3(R)-Aminohexahydroazepin-1-yl]-8-chloro-1-cyclopropyl- 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride 【CA登记号】141388-76-3 (free base),405165-61-9(hydrochloride) 【 分 子 式 】C19H22Cl2FN3O3 【 分 子 量 】430.3002 |
【开发单位】Bausch & Lomb; InSite Vision; SSP 【药理作用】Fluoroquinolone antibacterial |
合成路线1
【1】 Harms AE. 2008. Process for preparation of azepanylfluoroquinolonecarboxylates from chloroquinolines and azepan derivatives and their use as antibacterials. US 2008176834(Bausch and Lomb Inc, USA). |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 67063 | (S,Z)-N-(3-nitrobenzylidene)azepan-3-amine | C13H17N3O2 | 详情 | 详情 | |
(II) | 11684 | 8-Chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | 101987-89-7 | C13H8ClF2NO3 | 详情 | 详情 |
(III) | 67064 | (S,Z)-8-chloro-1-cyclopropyl-6-fluoro-7-(3-((3-nitrobenzylidene)amino)azepan-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | C26H24ClFN4O5 | 详情 | 详情 |
Extended Information