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【结 构 式】 
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【药物名称】CDRI-87/144 【化学名称】5(6)-(4-Methylpiperidin-1-ylcarbonyl)benzimidazole-2-carbamic acid methyl ester 【CA登记号】128579-70-4 【 分 子 式 】C16H20N4O3 【 分 子 量 】316.3628 |
【开发单位】Central Drug Research Institute (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Treatment of Helminthic Diseases |
合成路线1
The reaction of 4-chloro-3-nitrobenzoic acid (I) with thionyl chloride gives the acid chloride (II) which, by reaction with 4-methylpiperidine, affords the amide (III). Amination of (III) with methanolic ammonia followed by reduction of the nitro group gives the diamine compound (IV), which reacts with 1,3-bis(methoxycarbonyl)-S-methylisothiourea affording CDRI-87-144.
| 【1】 Beard, C.C. (Syntex (USA), Inc.); 5(6)-Benzene ring substd. benzimidazole-2-carbamate derivs. having anthelmintic activity. US 4086235 . |
| 【2】 Arya, V.P.; CDRI-87-144. Drugs Fut 1991, 16, 5, 420. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14485 | 3-nitro-4-chlorobenzoic acid; 4-chloro-3-nitrobenzoic acid | 96-99-1 | C7H4ClNO4 | 详情 | 详情 |
| (II) | 14486 | 4-Chloro-3-nitrobenzoylchloride; 4-chloro-3-nitrobenzoyl chloride | 38818-50-7 | C7H3Cl2NO3 | 详情 | 详情 |
| (III) | 14487 | (4-chloro-3-nitrophenyl)(4-methylpiperidino)methanone | C13H15ClN2O3 | 详情 | 详情 | |
| (IV) | 14488 | (3,4-diaminophenyl)(4-methylpiperidino)methanone | C13H19N3O | 详情 | 详情 |
Extended Information