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【结 构 式】 
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【药物名称】Neticonazole hydrochloride, SS-717, Newral, Atolant 【化学名称】(E)-1-[2-(Methylthio)-1-(2-pentyloxyphenyl)vinyl]-1H-imidazole hydrochloride 【CA登记号】130773-02-3, 130726-68-0 (free base), 111788-99-9 (undefined isomer) 【 分 子 式 】C17H23ClN2OS 【 分 子 量 】338.90266 |
【开发单位】SSP (Originator), Baker Cummins (Licensee), Mitsubishi Pharma (Licensee) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY |
合成路线1
The reaction of 2-bromo-2'-hydroxyacetophenone (I) with sodium methylmercaptide in methanol gives 2'-hydroxy-2-(methylthio)acetophenone (II), which is condensed with imidazole (III) by means of SOCl2 in dichloromethane to afford (E)-1-[1-(2-hydroxyphenyl)-2-(methylthio)vinyl]-1H-imidazole (IV), along with some of the (Z)-isomer. Finally, (IV) is condensed with pentyl bromide (V) by means of KOH in DMF.
| 【1】 Ogawa, M.; Matsuda, H.; Asaoka, T.; Oono, J.; Katori, T. (SSP Co., Ltd.); Imidazole derivs. EP 0227011; JP 1988146864; US 4740601 . |
| 【2】 Matsuda, H.; Iwasa, A.; Asaoka, T.; Nakashima, T.; Eto, H.; Kuraishi, T.; Ogawa, M.; Yamaguchi, K.; Synthesis and antifungal activities of a series of (1,2-disubstituted vinyl)imidazoles. Chem Pharm Bull 1991, 39, 9, 2301. |
| 【3】 Fromtling, R.A.; Castaner, J.; Neticonazole Hydrochloride. Drugs Fut 1993, 18, 4, 324. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14456 | 2-bromo-1-(2-hydroxyphenyl)-1-ethanone | 2491-36-3 | C8H7BrO2 | 详情 | 详情 |
| (II) | 14457 | 1-(2-hydroxyphenyl)-2-(methylsulfanyl)-1-ethanone | C9H10O2S | 详情 | 详情 | |
| (III) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (IV) | 14459 | 2-[(E)-1-(1H-imidazol-1-yl)-2-(methylsulfanyl)ethenyl]phenol | C12H12N2OS | 详情 | 详情 | |
| (V) | 14460 | 1-bromopentane; n-Amyl Bromide | 110-53-2 | C5H11Br | 详情 | 详情 |