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【结 构 式】 
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【药物名称】Wy-50295 tromethamine 【化学名称】S-(+)-alpha-Methyl-6-(2-quinolinylmethoxy)-2-naphthaleneacetic acid 2-hydroxy-1,1-bis(hydroxymethyl)ethylamine salt 【CA登记号】123016-21-7 (free acid) 【 分 子 式 】C27H30N2O6 【 分 子 量 】478.54995 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Lipoxygenase Inhibitors |
合成路线1
Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III). This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).
| 【1】 Kreft, A.F.; Musser, J.H.; Bicksler, J.J.; Giberson, J.W.; Kubrak, D.M. (American Home Products Corp.); 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents. AU 8819209; EP 0301813; GB 2207428; US 5208344 . |
| 【2】 Riegl, J.; Maddox, M.L.; Harrison, I.T.; Determination of the absolute configurations of (+)-2-(6-methoxy-2-naphthyl)propionic acid. J Med Chem 1974, 17, 377. |
| 【3】 Kreft, A.; Musser, J.; Marshall, L.; Grimes, D.; Wy-50,295 TROMETHAMINE. Drugs Fut 1990, 15, 8, 805. |
Extended Information