Aprosulate sodium, LW-10082, -Drug Synthesis Database

【结构式】

【药物名称】Aprosulate sodium, LW-10082

【化学名称】Hexadecasodium N,N'-1,3-propanediylbis [2,3,5,6-tetra-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-beta-D-galactopyranosyl)-D-gluconamide]
　　　　　　N,N'-Trimethylenebis[lactobionamide] hexadecakis(sodium sulfate) ester

【CA登记号】123072-45-7

【分子式】C₂₇H₃₄N₂Na₁₆O₇₀S₁₆

【分子量】2387.40423

【开发单位】Sankyo (Originator)

【药理作用】Anticoagulants, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS

合成路线1

One-pot reaction of calcium lactobionate (calcium 4-O-beta-D-galactopyranosyl-D-gluconate) (I) with Lewatit S1010, 1,3-diaminopropane (II) in dimethylformamide, SO3-pyridine complex and aqueous sodium hydroxide.

参考文献中间体

【1】 Meinetsberger, E. (Sankyo Pharma GmbH); Polysulfuric ester of amides of bis-aldonic acids and their derivs., process for their preparation and medicine. EP 0312086; US 5008247 .
【2】 Meinetsberger, E. (Sankyo Pharma GmbH); Bis-aldonic acid amide and process for their preparation. EP 0312087; US 5037973 .
【3】 Graul, A.; Castaner, J.; Prous, J.; Aprosulate Sodium. Drugs Fut 1994, 19, 8, 721.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13709	4-O-(beta-D-Galactopyranosyl)-D-gluconic acid calcium salt		C₁₂H₂₁CaO₁₂	详情	详情
(II)	19931	(2S)-2-[((2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl)amino]propionic acid		C₂₁H₂₅N₃O₄	详情	详情

Extended Information