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【结 构 式】 
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【药物名称】 【化学名称】6-Chloro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]-1,8-naphthyridine-3-carboxylic acid hydrochloride 【CA登记号】 【 分 子 式 】C15H16Cl2N4O3S 【 分 子 量 】403.28977 |
【开发单位】Nippon Shinyaku (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Naphthyridines |
合成路线1
Adamantylbenzoic acid (I) was converted to acid chloride (II) on treatment with SOCl2, and subsequently condensed with allyl p-hydroxybenzoate (III) in the presence of Et3N to afford the benzoyloxybenzoic ester (IV). The allyl ester was then cleaved by refluxing in aqueous ethanol in the presence of tris(triphenylphosphine)rhodium chloride to yield the title compound.
| 【1】 Shroot, B.; Eustache, J.; Bernardon, J.-M. (CIRD Galderma); Aromatic esters and thioesters, process for their preparation and their use in human or animal therapeutics and in cosmetics. AU 8928608; EP 0325540 . |
| 【2】 Eustache, J.; Bernardon, J.-M.; Shroot, B. (CIRD Galderma); Aromatic esters and thioesters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compsns.. US 5173289 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21020 | 3-(1-adamantyl)-4-methoxybenzoic acid | C18H22O3 | 详情 | 详情 | |
| (II) | 21021 | 3-(1-adamantyl)-4-methoxybenzoyl chloride | C18H21ClO2 | 详情 | 详情 | |
| (III) | 21022 | allyl 4-hydroxybenzoate | C10H10O3 | 详情 | 详情 | |
| (IV) | 21023 | 4-[(allyloxy)carbonyl]phenyl 3-(1-adamantyl)-4-methoxybenzoate | C28H30O5 | 详情 | 详情 |
Extended Information