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【结 构 式】 
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【药物名称】Wy-50295 【化学名称】(+)-(S)-2-[6-(2-Quinolinylmethoxy)-2-naphthyl]propionic acid 【CA登记号】123016-21-7 【 分 子 式 】C23H19NO3 【 分 子 量 】357.41278 |
【开发单位】Wyeth Pharmaceuticals (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Lipoxygenase Inhibitors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.
| 【1】 Kreft, A.F.; Failli, A.; Musser, J.H.; et al.; Conversion of a cyclooxygenase (CO) inhibitor into a 5-lipoxygenase (LO) inhibitor - A general route to novel antiinflammatory and antiallergy drugs. Drugs Exp Clin Res 1991, 17, 381-387. |
| 【2】 Kreft, A.; Musser, J.; Substituted-[2-Quinolinyl(Bridged)Aryl] compounds: Modulators of eicosanoid biosynthesis and action. Drugs Fut 1990, 15, 1, 73. |
| 【3】 Marshall, L.A.; Wong, A.; Kreft, A.F.; Structure -activity relationships in the quinoline- containing class of inhibitors of 5-lipoxygenase (5-LO) enzyme translocation and activation. Drugs Fut 1994, 19, 3, 255. |
Extended Information