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【结 构 式】 
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【药物名称】NS-1, OCO-1112 【化学名称】4-[2-(4-Isopropylbenzamido)ethoxy]benzoic acid 【CA登记号】113079-40-6 【 分 子 式 】C19H21NO4 【 分 子 量 】327.38352 |
【开发单位】Nippon Shinyaku (Originator) 【药理作用】Lipoprotein Disorders, Treatment of , METABOLIC DRUGS |
合成路线1
The condensation of aziridine (I) with methyl 4-hydroxybenzoate (II) in refluxing chloroform gives methyl 4-(2-aminoethoxy)benzoate (III), which is acylated with 4-isopropylbenzoyl chloride by means of K2CO3 in chloroform yielding methyl 4-[2-(4-isopropylbenzamido)ethoxy]benzoate (IV). Finally, this compound is hydrolyzed with NaOH in refluxing water.
| 【1】 Yoshikuni, Y.; Choaki, S.; Ozaki, T.; Yoshida, H. (Nippon Shinyaku Co., Ltd.); Benzoic acid derivs. CH 674204; DE 3718765; FR 2600059; GB 2191487; JP 1987292754; JP 1988159359; US 4831055 . |
| 【2】 Prous, J.; Castaner, J.; NS-1. Drugs Fut 1990, 15, 7, 682. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 41310 | 4-isopropylbenzoyl chloride | C10H11ClO | 详情 | 详情 | ||
| (I) | 10151 | Ethyleneimine; Aziridine; Azirane | 151-56-4 | C2H5N | 详情 | 详情 |
| (II) | 10251 | methyl 4-hydroxybenzoate; Methyl p-hydroxybenzoate | 99-76-3 | C8H8O3 | 详情 | 详情 |
| (III) | 12457 | methyl 4-(2-aminoethoxy)benzoate | C10H13NO3 | 详情 | 详情 | |
| (IV) | 12458 | methyl 4-[2-[(4-isopropylbenzoyl)amino]ethoxy]benzoate | C20H23NO4 | 详情 | 详情 |
Extended Information