【结 构 式】 |
【药物名称】Iosimide, Univist 【化学名称】2,4,6-Triiodobenzene-1,3,5-tricarboxylic acid tris[bis(2-hydroxyethyl)]triamide 【CA登记号】79211-10-2 【 分 子 式 】C21H30I3N3O9 【 分 子 量 】849.20115 |
【开发单位】Schering AG (Originator) 【药理作用】Contrast Mediums, DIAGNOSTIC AGENTS |
合成路线1
The amino group of iodamic acid (I) is converted to the nitrile (II) via diazotization and a Sandmeyer reaction. Subsequent hydrolysis via the amide (III) yields triiodotrimesic acid (IV). The trichloride of this acid (V) is converted to iosimide by reaction with diethanolamine.
【1】 Gries, H.; Pfeiffer, H.; Speck, U.; Mutzel, W. (Schering AG); Non-ionic 5-C substd. 2,4,6-triiodo-isophthalic ac. DE 3001292; EP 0032387; US 5047228 . |
【2】 Gries, H.; Iosimide. Drugs Fut 1988, 13, 3, 228. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 22006 | 5-amino-2,4,6-triiodoisophthalic acid | 35453-19-1 | C8H4I3NO4 | 详情 | 详情 |
(II) | 22007 | 5-cyano-2,4,6-triiodoisophthalic acid | C9H2I3NO4 | 详情 | 详情 | |
(III) | 22008 | 5-(aminocarbonyl)-2,4,6-triiodoisophthalic acid | C9H4I3NO5 | 详情 | 详情 | |
(IV) | 22009 | 2,4,6-triiodo-1,3,5-benzenetricarboxylic acid | C9H3I3O6 | 详情 | 详情 | |
(V) | 22010 | 2,4,6-triiodo-1,3,5-benzenetricarbonyl trichloride | C9Cl3I3O3 | 详情 | 详情 |
Extended Information