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【结 构 式】 
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【药物名称】P-0285 【化学名称】Methyl 2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyri-dine-3,5-dicarboxylate 【CA登记号】91040-25-4 【 分 子 式 】C28H30Cl2N4O6 【 分 子 量 】589.4805 |
【开发单位】Pierrel (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Hypertension, Treatment of, Calcium Channel Blockers |
合成路线1
Hantzsch condensation of 2-[4-(3,4-dichlorophenyl)piperazin-1-yl]ethyl acetylacetate (III) with methyl 3-aminocrotonate (II) and 3-nitrobenzaldehyde (I) in eftuxing isopropanol affords title compound.
| 【1】 Zumin Tricerri, S.; Casagrande, C.; De Marchi, F.; Nicola, M. (Pierrel SpA); Dihydropyridines with an antagonistic activity to . EP 0097821; US 4894460 . |
| 【2】 Bani, M.; Favara, D.; P-0285. Drugs Fut 1988, 13, 4, 321. |
Extended Information