Loxiglumide, CR-1505, Loxizin, -Drug Synthesis Database

【结构式】

【药物名称】Loxiglumide, CR-1505, Loxizin

【化学名称】(±)-4-(3,4-Dichlorobenzamido)-N-(3-methoxypropyl)-N-phenylglutaramic acid
　　　　　　(±)-4-(3,4-Dichlorobenzamido)-5-[N-(3-methoxypropyl)pentylamino)-5-oxopentanoic acid

【CA登记号】107097-80-3

【分子式】C₂₁H₃₀Cl₂N₂O₅

【分子量】461.38965

【开发单位】Rotta (Originator), Mitsubishi Pharma (Licensee), Kaken (Codevelopment)

【药理作用】GASTROINTESTINAL DRUGS, Pancreatic Disorders, Treatment of, CCK1 (CCKA) Antagonists

合成路线1

By condensation of N-(3,4-dichlorobenzoyl)-glutamic acid anhydride (I) with N-(3-methoxypropyl)-N-pentylamine (II) in water at 5 C.

参考文献中间体

【1】 Makovec, F.; Chistè, R.; Rovati, C.L.; Rovati, A.L. (Rotta Research Laboratorium SpA); Pharmaceutically active derivatives of glutamic and aspartic acids. WO 8703869 .
【2】 Patoia, L.; Prous, J.; Castaner, J.; LOXIGLUMIDE. Drugs Fut 1990, 15, 1, 32.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12129	3,4-Dichloro-N-(2,6-dioxotetrahydro-2H-pyran-3-yl)benzamide		C₁₂H₉Cl₂NO₄	详情	详情
(II)	12130	N-(3-Methoxypropyl)-N-pentylamine; N-(3-Methoxypropyl)-1-pentanamine		C₉H₂₁NO	详情	详情

Extended Information