Fotemustine, S-10036, Servier-10036, Muphoran, -Drug Synthesis Database

【结构式】

【药物名称】Fotemustine, S-10036, Servier-10036, Muphoran

【化学名称】(±)-[1-[3-(2-Chloroethyl)-3-nitrosoureido]ethyl]phosphonic acid diethyl ester

【CA登记号】92118-27-9

【分子式】C₉H₁₉ClN₃O₅P

【分子量】315.69568

【开发单位】ADIR (Originator), Servier (Originator), Italfarmaco (Licensee)

【药理作用】Brain Cancer Therapy, Oncolytic Drugs, DNA-Damaging Drugs

合成路线1

The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III), which is then treated with sodium nitrite and formic acid.

参考文献中间体

【1】 Lavielle, G.; Cudennec, C. (ADIR et Cie.); New nitrosourea derivs., process for preparing them and pharmaceutical compsns. containing them. FR 2536075 .
【2】 Prous, J.; Castaner, J.; FOTEMUSTINE < Rec INN >. Drugs Fut 1989, 14, 11, 1042.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11237	1-Chloro-2-isocyanatoethane; 2-Chloroethyl isocyanate	1943-83-5	C₃H₄ClNO	详情	详情
(II)	19534	diethyl 1-aminoethylphosphonate		C₆H₁₆NO₃P	详情	详情
(III)	19535	diethyl 1-([[(2-chloroethyl)amino]carbonyl]amino)ethylphosphonate		C₉H₂₀ClN₂O₄P	详情	详情

Extended Information