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【结 构 式】 
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【药物名称】Elbanizine, HWA-214 【化学名称】2,6-Dimethyl-3-nitro-4-[2-(4-diphenylmethyl-1-piperazinyl)ethylamino]pyridine 【CA登记号】110629-41-9 【 分 子 式 】C26H31N5O2 【 分 子 量 】445.56927 |
【开发单位】Aventis Pharma (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, RESPIRATORY DRUGS, Histamine H1 Antagonists, Mediator Release Inhibitors, Platelet-Activating Factor (PAF) Antagonists |
合成路线1
The reaction of 3-acetyl-6-methyl-3,4-dihydro-2H-pyran-2,4-dione (I) with ammonia gives 2,6-dimethylpyridin-4-ol (II), which is nitrated with HNO3/H2SO4 and treated with SOCl2 to yield 4-chloro-2,6-dimethyl-3-nitropyridine (III). The condensation of (III) with ethanolamine (IV) affords N-(2,6-dimethyl-3-nitropyridin-4-yl)ethanolamine (V), which is finally condensed with 1-(diphenylmethyl)piperazine (VI) by means of SOCl2 and treated with HCl to furnish the target trihydrochloride.
| 【1】 (Aventis SA); Pyridine derivs.. DE 3541428; EP 0224159; JP 1987129271; US 4792554 . |
| 【2】 Elben, U.; SUBSTITUTED DIALKYLPYRIDINES AND THEIR N-OXIDES WITH AN ELECTRON-WITHDRAWING SUBSTITUENT. Drugs Fut 1989, 14, 10, 981. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43660 | 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione | 520-45-6 | C8H8O4 | 详情 | 详情 |
| (II) | 43661 | 2,6-dimethyl-4-pyridinol | C7H9NO | 详情 | 详情 | |
| (III) | 43662 | 4-chloro-2,6-dimethyl-3-nitropyridine | C7H7ClN2O2 | 详情 | 详情 | |
| (IV) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |
| (V) | 43663 | 2-[(2,6-dimethyl-3-nitro-4-pyridinyl)amino]-1-ethanol | C9H13N3O3 | 详情 | 详情 | |
| (VI) | 20796 | N-(Benzhydryl)piperazine; 1-Benzhydrylpiperazine; 1-(dibenzyl)piperazine | 841-77-0 | C17H20N2 | 详情 | 详情 |