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【结 构 式】 
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【药物名称】Enalapril maleate, MK-421, Ednit, Ditensor, Dabonal, Baripril, Crinoren, Xanef, Renitec, Enapren, Innovace, Innovace Melt(freeze-dried oral wafer), Lexxel(comb. with felodipine), Renivace, Vasotec 【化学名称】(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline maleate 【CA登记号】76095-16-4, 75847-73-3 (free base) 【 分 子 式 】C24H32N2O9 【 分 子 量 】492.53064 |
【开发单位】Merck & Co. (Originator), Merck Sharp & Dohme (Originator), Almirall Prodesfarma (Licensee), Banyu (Licensee), Uriach (Licensee), Vita (Licensee) 【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy, Hypertension, Treatment of, OCULAR MEDICATIONS, Ophthalmic Drugs, Angiotensin-I Converting Enzyme (ACE) Inhibitors |
合成路线1
By reductocondensation of ethyl 2-oxo-4-phenylbutyrate (I) with alanylproline (II) by means of sodium cyanoborohydride or H2 over Raney-Ni or Pd/C in water.
| 【1】 Patchett, A.A.; et al.; A new class of angiotensin-converting anzyme inhibitors. Nature 1980, 288, 280-283. |
| 【2】 Hopkins, S.J.; Serradell, M.N.; Blancafort, P.; Castaner, J.; Enalapril maleate. Drugs Fut 1982, 7, 8, 556. |