【结 构 式】 |
【药物名称】Trombodipine, PCA-4230 【化学名称】2,4,6-Trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 2-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzisothiazol-2-yl)ethyl ethyl diester 【CA登记号】113658-85-8 【 分 子 式 】C21H24N2O7S 【 分 子 量 】448.49863 |
【开发单位】Alter (Originator) 【药理作用】Antiplatelet Therapy, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS |
合成路线1
The reaction between acetaldehyde (I), ethyl 3-aminocrotonate (II) and acetoacetate (III) in ethanolic medium yields the corresponding 1,4-dihydropyridine.
【1】 Sunkel, C.; Fau de Casa-Juana, M.; Dorrego, F.; Priego, J.; Ortega, P.; Cillero, J. (Alter SA); 1,4-Dihydropyridines, processes for their preparation and their use as antithrombotic drugs. DE 3617976; EP 0253092; US 4782069 . |
【2】 Ortega, M.P.; Priego, J.G.; Fau de Casa-Juana, M.; Cillero, F.J.; Sunkel, C.E.; Trombodipine. Drugs Fut 1992, 17, 6, 465. |
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