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【结 构 式】 
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【药物名称】Lomerizine hydrochloride, DE-090, KB-2796, Terranas, Migsis 【化学名称】1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxy-benzyl)piperazine dihydrochloride 【CA登记号】101477-54-7, 101477-55-8 (free base) 【 分 子 式 】C27H32Cl2F2N2O3 【 分 子 量 】541.47049 |
【开发单位】Nippon Organon (Originator), Pfizer (Licensee), Santen (Licensee) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Antiglaucoma Agents, Antimigraine Drugs, Migraine, Prophylactic Treatment of, OCULAR MEDICATIONS, Ophthalmic Drugs, Calcium Channel Blockers, P-Glycoprotein (MDR-1) Inhibitors |
合成路线1
By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.
| 【1】 Stukamoto, G.; Kanazawa, T.; Ohtaka, H.; Ito, K.; Benzylpiperazine derivatives. IV. Synthesis and ce. Chem Pharm Bull 1987, 35, 8, 3270. |
| 【2】 Ito, K.; Kanazawa, T.; Ohtaka, H.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.); 1-(2,3,4-Tri-methoxybenzyl)-4[bis(4-fluorophenyl)m. EP 0159566; ES 8702393; ES 8801236; ES 8801237; JP 1985222472; US 4663325 . |
| 【3】 Prous, J.; Castaner, J.; KB-2796. Drugs Fut 1988, 13, 4, 312. |
Extended Information