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【结 构 式】 
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【药物名称】Edaravone, MCI-186, Radicut 【化学名称】3-Methyl-1-phenyl-2-pyrazolin-5-one 【CA登记号】89-25-8, 94489-23-3 (NH3 salt) 【 分 子 式 】C10H10N2O 【 分 子 量 】174.204 |
【开发单位】Mitsubishi Pharma (Originator) 【药理作用】Amyotrophic Lateral Sclerosis, Agents for, Cerebrovascular Diseases, Treatment of, Hemorrhagic Stroke, Treatment of, Neurodegenerative Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Antioxidants, Free Radical Scavengers |
合成路线1
By direct cyclization of phenylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol.
| 【1】 Graul, A.; Castaner, J.; Edaravone. Drugs Fut 1996, 21, 10, 1014. |
| 【2】 Nishi, H.; Watanabe, T.; Yuki, S.; Morinaka, Y.; Iseki, K.; Sakurai, H. (Mitsubishi Chemical Corp.); Prophylactic and therapeutic agent for circulatory disorders. EP 0208874; JP 1987108814; US 4857542 . |
Extended Information