【结 构 式】 |
【药物名称】HWA-152 【化学名称】3-Cyano-2,6-dimethyl-4-(4-thiomorpholinyl)pyridine N-oxide hydrochloride 【CA登记号】106101-15-9, 106101-47-7 (free base) 【 分 子 式 】C12H16ClN3OS 【 分 子 量 】285.79782 |
【开发单位】Cassella (Originator) 【药理作用】Cognition Disorders, Treatment of, NEUROLOGIC DRUGS |
合成路线1
The cyclization of ethyl acetoacetate (I) with 3-amino-2-butenenitrile (II) gives 4-hydroxy-2,6-dimethylpyridine-3-carbonitrile (III), which is treated with SOCl2 and oxidized with MCPBA to yield 4-chloro-2,6-dimethylpyridine-3-carbonitrile N-oxide (IV). Finally, this compound is condensed with thiomorpholine (V) to afford the target compound.
【1】 Greve, W.; Schindler, U.; Elben, U.; Rudolphi, K. (Aventis Pharma AG); Substd. pyridin-1-oxides, process for their preparation, medicines containing them and their use. DE 3514073 . |
【2】 Nemcova, D.; Janata, V.; 4-Hydroxy-2,6-dimethylnicotinic acid esters. CS 147252 . |
【3】 Elben, U.; SUBSTITUTED DIALKYLPYRIDINES AND THEIR N-OXIDES WITH AN ELECTRON-WITHDRAWING SUBSTITUENT. Drugs Fut 1989, 14, 10, 981. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 11819 | ethyl acetoacetate; ethyl 3-oxobutanoate;Acetoacetic ester;Ethyl beta-ketobutyrate;ethyl 3-oxobutyrate | 141-97-9 | C6H10O3 | 详情 | 详情 |
(II) | 28381 | (E)-3-amino-2-butenenitrile | 1118-61-2 | C4H6N2 | 详情 | 详情 |
(III) | 43658 | 4-hydroxy-2,6-dimethylnicotinonitrile | C8H8N2O | 详情 | 详情 | |
(IV) | 43659 | 4-chloro-3-cyano-2,6-dimethyl-1-pyridiniumolate | C8H7ClN2O | 详情 | 详情 | |
(V) | 36317 | thiomorpholine | 123-90-0 | C4H9NS | 详情 | 详情 |
Extended Information